l-carnitine as a water soluble derivative of lysine has a crucial biological role in lipid metabolism. present experiment was conducted to study the effect of l-carnitine supplementation into broiler and/or breeder diets on broilers' performance, blood related factors, carcass characteristics and immune system. l-carnitine was added to the broiler breeder's diets at levels of 0, and 6...

Modulatory effects of l-carnitine, acetate, propionate, and 5-tetradecyloxy-2-furoic acid (TOFA; an inhibitor acetyl-CoA carboxylase) on oxidation esterification [1-14C]-palmitate were studied in hepatocytes isolated from phlorizin-treated control wethers. Our hypotheses that (1) palmitate would be greater sheep injected with phlorizin; (2) l-carnitine increase more (3) acetate propionate decre...

This study aimed to evaluate the rumen protective effectiveness of L-carnitine through in vitro tests, degradation tests and vivo tests. Twelve rumen-fistulated crossbred rams with similar body weights 55±3.6 kg ages 3±0.2 years old were divided into three treatment groups a 3×3 Latin square design, G1 (basal diet no additives), G2 (unprotected L-carnitine) or G3 (rumen-protected L-carnitine). ...

Previous findings in rats and in human vegetarians suggest that the plasma carnitine concentration and/or carnitine ingestion may influence the renal reabsorption of carnitine. We tested this hypothesis in rats with secondary carnitine deficiency following treatment with N-trimethyl-hydrazine-3-propionate (THP) for 2 weeks and rats treated with excess L-carnitine for 2 weeks. Compared to untrea...

Background: The benefit effect of L-carnitine is proposed for treatment of obesity as long time periods. So, in the present study, effect of L-carnitine on serum FSH, LH and testosterone levels in adult male rats is evaluated. Materials and Methods: Rats were treated different doses of L-carnitine tartarate daily for 16 days, peritoneally. The control group was treated saline as vehicle. After ...

Aim: We measured carnitine levels in patients with carnitine including dialysis patients, and examined whether administration of L-carnitine improved muscle symptoms. Methods: We measured carnitine levels in 27 patients with liver cirrhosis who were receiving treatment in our hospital, and administered L-carnitine (600 mg 1800 mg) to patients having muscle cramps for approximately one month and...

carnitine is a water-soluble quaternary amine which increases the long-chain fatty acid metabolism by facilitation of their transport to the oxidation site (mitochondria). carnitine most likely is present in all animal species, in many microorganisms, and in many plants. in this study, we determined the carnitine level of sera in pregnant and non-pregnant women by segade modified method. averag...

The effect of short- and long-term feeding with L-carnitine, L-acetyl carnitine and L-propionyl carnitine on the production of eicosanoids from in vitro stimulated carrageenan-induced rat peritoneal macrophages was investigated. Both young (4 weeks) and old (18 months) rats were used. A lower number of cells was isolated from the peritonea of treated than control young rats after 4 d feeding, b...

Acetylation of added (-)carnitine by heart mitochondira coupled to the oxidation of pyruvate in the presence of malonate was inhibited, apparently competitively, by long chain acyl(+)carnitines although the activity of carnitine acetyltransferase (EC 2.3.1.7) itself was not affected. Mitochondria have been found to possess a translocase system that allows the transport of carnitine and acylcarn...