The aim of this investigation was to evaluate effectiveness of RM-33, a new isoxazolotriazepine, in the model of carrageenan-induced inflammation in rats. Wistar rats were pretreated with intraperitoneal (ip) or oral (po) doses of RM-33, at daily doses ranging from 250 to 1000 microg, administered 1-3 days before elicitation of the carrageenan reaction. We showed that both routes of RM-33 admin...

Obesity is associated with several co-morbidities including chronic pain. Systemic low-grade inflammation and dysregulation of pro-inflammatory cytokines have been proposed to underlie these phenomena. This study characterized pain inflammation, levels the cytokine visfatin, in a rodent model obesity, investigated whether treatment visfatin inhibitor, FK866, has anti-inflammatory and/or analges...

This study aimed to evaluate Helychrisum faradifani hydro alcoholic extract activity on the vascular and cellular phases of inflammation in mice. Carrageenan was injected hind-paw effect edema acetic acid 0.6 % by intra peritoneal route H. permeability. Cotton pellets imbibed with 1% carrageenan inserted skin animals investigate granuloma formation. Indomethacin at dose 10 mg/kg administered or...

BACKGROUND Common cold is caused by a variety of respiratory viruses. The prevalence in children is high, and it potentially contributes to significant morbidity. Iota-carragenan, a polymer derived from red seaweed, has reduced viral load in nasal secretions and alleviated symptoms in adults with common cold. METHODS We have assessed the antiviral and therapeutic activity of a nasal spray con...

Implantation of Walker 256 tumor decreases acute systemic inflammation in rats. Inflammatory hyperalgesia is one of the most important events of acute inflammation. The L-arginine/NO/cGMP/K(+)ATP pathway has been proposed as the mechanism of peripheral antinociception mediated by several drugs and physical exercise. The objective of this study was to investigate a possible involvement of the NO...

Carrageenans are sulfated polysaccharides extracted from the cell wall of some marine red algae. These polysaccharides are widely used as gelling, stabilizing, and viscosifying agents in the food and pharmaceutical industries. Since the rheological properties of these polysaccharides depend on their sulfate content, we screened several isolated marine bacteria for carrageenan specific sulfatase...

Statins are among the most prescribed drugs in recent clinical practice. They are also known for their pleiotropic actions, which are independent of their lipid-lowering properties. The effect of lovastatin was investigated against carrageenan-induced paw edema in male Wistar rats (200-250 g) and on leukocyte migration, as measured by carrageenan-induced peritonitis in male Swiss mice (20-25 g)...

Curcumin, a hydrophobic polyphenol compound derived from the rhizome of the Curcuma genus, has a wide spectrum of biological and pharmacological applications. Previously, curcumin nanoparticles with different stabilizers had been produced successfully in order to enhance solubility and per oral absorption. In the present study, we tested the anti-inflammatory effect of d-α-Tocopheryl polyethyle...

Background: Nanomaterials are extensively used from household applications to industrial applications. Nanomaterials are the substances that are synthesized in the size ranging from 1-100 nm which exhibits excellent physical and chemical properties compared to their bulk forms. Iron oxide nanoparticles (magnetic) have unique properties that make them applicable in drug delivery applications. Ho...