BACKGROUND It has been reported that hyperglycemia can induce endothelial dysfunction via increased oxidative stress and that it plays a central role in the development of atherosclerosis and coronary heart disease. Phyllanthus emblica (Emblica officinalis, amla) is known for its antioxidant and antihyperlipidemic activity. The present study compared the effects of an aqueous extract of P. embl...

considering the high prevalence of osteoarthritis (oa) and since until now there has not been any human studies to evaluate the effect of sesame in oa patients, this study was designed to assess the effect of administration of sesame on inflammation and oxidative stress in patients with knee oa. fifty patients with knee oa were allocated into two groups namely control and sesame group. 25 patie...

We performed a cross-sectional, multicentre study in Japan to detect the differences in biomarkers of exposure and cardiovascular biomarkers between smokers and non-smokers. Several clinically relevant cardiovascular biomarkers differed significantly between smokers and non-smokers, including lipid metabolism (high-density lipoprotein cholesterol concentrations - lower in smokers), inflammation...

This review article is intended to describe how oxidative stress regulates cardiovascular disease development and progression. Epigenetic mechanisms related to oxidative stress, as well as more reliable biomarkers of oxidative stress, are emerging over the last years as potentially useful tools to design therapeutic approaches aimed at modulating enhanced oxidative stress "in vivo", thereby mit...

The aim of the present observational study was to investigate the relationships between glycaemic status and levels of oxidative stress and inflammation in well-controlled type 2 diabetes subjects. Metabolic variables (weight, BMI, waist circumference (waist), blood glucose, glycated Hb (HbA(1c)), insulin, blood lipids), biomarkers of oxidative stress (8-iso-PGF(2alpha), malondialdehyde, 8-oxo-...

Previous epidemiologic observational and experimental studies investigated the potential of antioxidant micronutrients to modulate cancer risk, but these studies produced inconsistent results. In this pilot, randomized, double-blind, placebo-controlled clinical trial (n = 47), we assessed the effects of an antioxidant micronutrient combination (800 mg dl-alpha-tocopherol acetate, 24 mg beta-car...

objective(s): silver nanoparticles (ag-nps) are one of the most widely used nanomaterials recently. despite the wide application of nanomaterials, there is limited information concerning their impact on human health and the environment. this study aimed to find the effects of ag-nps (40 nm) on blood serum, liver and kidney tissues of homing pigeons (columbia livia).materials and methods: columb...

background: consumption of dark chocolate has been often hypothesized to have a role in the prevention of chronic diseases. the objective of this study was to investigate the effects of consumption of dark chocolate (dc) on serum oxidative stress and blood pressure in patients with metabolic syndrome (mets). methods: an 8-week parallel randomized clinical trial involving 114 patients with mets ...