The goal of this research is to develop a spectrofluorometric method for analyzing carvedilol in pharmaceutical preparations and apply the formulations. method’s calibration curve was plotted between 25 500 ng/mL. mean equation from six replicate experiments y=1.8736x+7.7291. correlation coefficient value higher than 0.997 curve. trueness results were better 2.09% precision less 2.73% carvedilo...

OBJECTIVE Dilated cardiomyopathy is the end result of chronic iron overload in patients with beta thalassemia major. The objective of the present study was to evaluate the safety and efficacy of Carvedilol in patients with beta thalassemia major and dilated cardiomyopathy. METHODS During a six-month period, fourteen patients with beta-thalassemia major and heart failure without diabetes melli...

In this study, we examined acute effects of carvedilol, a nonselective alpha/beta-adrenergic receptor blocker, on neuronal transmission and long-term potentiation (LTP) in six month-old TgCRND8 mice and their wild-type age-matched controls. Field excitatory postsynaptic potentials were recorded in the CA1 region of the hippocampus from carvedilol- or vehicle dimethyl sulfoxide-treated slices, a...

BACKGROUND We evaluated the effect of coadministration of β-blocker (carvedilol) as the third agent with angiotensin II receptor blockers (ARB) and calcium channel blockers (CCB) on blood pressure (BP) regulation and glucose metabolism. METHODS Diabetic patients who did not achieve the therapeutic BP goal (140/90 mmHg) by ARB and CCB combination therapy were recruited. This study was designed...

Objective: To determine whether the process of reverse left ventricular remodelling in response to carvedilol is dependent on baseline heart rate (BHR), heart rhythm, or heart rate reduction (HRR) in response to carvedilol. Design: Retrospective analysis of serial echocardiograms in 257 patients with chronic systolic heart failure at baseline and at 12–18 months after starting carvedilol. Rever...

BACKGROUND Carvedilol and nebivolol have favourable properties such as anti-oxidative effects in addition to other beta-blockers. However, which of these drugs is more effective on oxidative stress is unclear. AIM To compare the effects carvedilol and nebivolol on oxidative stress status in non-ischaemic heart failure (HF) patients. METHODS We included 56 symptomatic non-ischaemic HF patien...

For many years, -adrenergic receptor antagonists ( -blockers or AR antagonists) have provided significant morbidity and mortality benefits in patients who have sustained acute myocardial infarction. More recently, -adrenergic receptor antagonists have been found to provide survival benefits in patients suffering from heart failure, although the efficacy of different -blockers varies widely in t...

BACKGROUND Beta-blockade is contraindicated in severe aortic regurgitation (AR) due to the fear of prolonging diastole and thus aggravate regurgitation. However, this has never been scientifically proven and positive effects of targeting the sympathetic system in AR has been demonstrated in several studies. METHOD Thirty-nine Sprague-Dawley rats with AR were randomized to ten weeks of medical...

OBJECTIVES To assess the beneficial effect of carvedilol treatment on infarct myocardium and the relation to the expression of nuclear factor-kappa B (NF-κB), Toll-like receptor 4 (TLR4), and β-arrestin 2. MATERIALS AND METHODS Rat myocardial infarction (MI) model was produced by ligating the left anterior descending coronary artery. Forty-eight rats were randomized to the following groups be...

Accepted March 11, 2009 The purpose of this study was to improve the solubility and dissolution rate of carvedilol by forming a ternary complex with b-cyclodextrin and citric acid and to formulate its mouth-dissolving tablets. The rationale for preparing mouth-dissolving tablet of carvedilol was to make the drug available in a soluble form in the mouth, which would facilitate its absorption fro...