Breast cancer is the most serious disease affecting women worldwide. Recently, breast cases reached 2.2 million people. The treatment method still developing. In addition, use of herbal medicine as a palliative therapeutic to chemical and/or synthetic drugs increasing. Ocimum sanctum Linn. popular plant in Indonesia and Southeast Asia countries also known an medi...

Purpose: Type 2 diabetes mellitus (T2DM) is a heterogeneous, chronic, and metabolic disease that affects significant proportion of the global population. This study aimed to evaluate effect NFKB1 -94 ATTG ins/del polymorphisms on expression apoptosis genes telomere length (TL) in patients with T2DM compared healthy individuals.
 Materials Methods: Sixty-nine sixty people were enrolled stud...

background: silymarin is a flavonolignan that has been the subject of research to evaluate the beneficial properties for decades. silymarin has been known for its potent cytoprotective, hepatoprotective and antioxidant activities. the goal of the present study was to gain a deeper understanding of possible molecular mechanisms of apoptosis of the injuries induced by silymarin on balb/c mice fet...

objective(s):the neuroprotective effect offruit aqueous extract of ziziphus jujuba lam on glucose-induced neurotoxicity in pc12 cells as an appropriate in vitro model of diabetic neuropathy was investigated. materials and methods: cell viability was determined by the mtt assay. cellular reactive oxygen species (ros) generation was measured by dcfh-da analysis. cleaved caspase-3, a biochemical p...

we aimed to develop a cost-effective and robust method to predict drug resistance in individualpatients. representative tissue fragments were obtained from tumors removed from femalepatients, aged 24-74 years old. the tumor tissue was taken by a histopathology’s or a surgeonunder sterile conditions. cells obtained by enzymatic dissociation from tumor after surgery, werecultured as a monolayer f...

objective(s): present study was performed in order to uncover new aspects for nicotine-induced damages on spermatogenesis cell lineage. materials and methods: for this purpose, 36 mature male wistar rats were divided into three groups as; control-sham (0.2 ml, saline normal, ip), low dose (0.2 mg/kg bw-1, ip) nicotine-received and high dose (0.4 mg/kg bw-1, ip) nicotine-received groups. followi...

Background: Caspase-3 is involved in the execution of apoptosis and widely used as an apoptotic marker. Tumor necrosis factor-α (TNF-α) released from activated macrophages has various functions such modulation cell growth differentiation, immunoregulation, coagulation, regulation endothelial function. This study investigated immunohistochemical staining caspase-3 TNF-α expression placentas preg...

Alternative splicing of caspase-3 produces a short isoform caspase-3s that antagonizes caspase-3 apoptotic activity. However, the mechanism of apoptosis inhibition by caspase-3s remains unknown. Here we show that exogenous caspase-3 sensitizes MCF-7 and HBL100 breast cancers cells to chemotherapeutic treatments such as etoposide and methotrexate whereas co-transfection with caspase-3s strongly ...