introduction: ischemia leads to loss of neurons by apoptosis in specific brain regions, especially in the hippocampus. the purpose of this study was investigating the effects of exercise preconditioning on expression of bax, bcl-2, and caspase-3 proteins in hippocampal ca1 neurons after induction of cerebral ischemia. methods: male rats weighing 260-300 g were randomly allocated into three grou...

soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and anti-proliferative effects have been studied in different cancer cells. however, the mechanisms of action of genistein and its molecular targets on human colon cells have not been fully elucidated. therefore, caspase-3 and p38 mitogen-activated protein kinase (p38 mapk) as the main therapeutic targets were...

Osteosarcoma is a highly malignant primary tumor on bone that mainly attacks children and young adolescents. Until now, osteosarcoma therapy still combines some high costs invasive modalities may give side effects, such as pain nausea. Our previous studies suggested non-contact electric field has anti-proliferative effect breast cancer cells, in vitro vivo. In this study, we were interested stu...

PURPOSE An inability to undergo apoptosis is widely thought to contribute to both tumorigenesis and tumor progression. One of the key mediators of apoptosis is the thiol protease caspase 3. In this investigation, caspase 3 mRNA and protein expression in breast cancer was examined. EXPERIMENTAL DESIGN Caspase 3 was measured at the mRNA level using reverse transcription-PCR and at the protein l...

Signal Transducer and Activator of Transcription-1 (STAT1) is phosphorylated upon interferon (IFN) stimulation, which can restrict cell proliferation and survival. Nevertheless, in some cancers STAT1 can act in an anti-apoptotic manner. Moreover, certain malignancies are characterized by the overexpression and constitutive activation of STAT1. Here, we demonstrate that the treatment of transfor...