Muley et al. (8) and Jadhav et al. (2) have recently shown histamine to be responsible for the cataleptic effect of morphine and clonidine in mice. Since amodiaquine is reported to inhibit histarnine-Nvrnethvl transferase, an enzyme concerned with major, catabolism of brain histamine by methylation (4), we have investigated the effect of pretreatment with amodiaquine on morphine-and clonidine-i...

articles contributed to the Edinburgh Medical Journal. After a review of the various opinions that have been held in England of late years concerning hypnotism, the author proceeds to describe the means used to hypnotise persons, dividing these, as is usually done, into those acting by mental suggestion and those acting by physical stimulation. In doing so, he does not clearly point out that mo...

Murraya koenigii L. (Rutaceae), commonly known as curry leaf tree, closely associated with south India where the word "curry" originates from the Tamil "kari" for spiced sauces. Curry leaves are a rich source of carbazole alkaloids which possess various biological activities such as antitumor, antioxidant and anti-inflammatory. Curry leaf has a potential role in the treatment of diabetes. Reser...

Current treatment options for parkinsonism as a neurodegenerative disease are limited and still mainly symptomatic and lack significant disease-modifying effect. Understanding its molecular pathology and finding the cause of dopaminergic cell loss will lead to exploring therapies that could prevent and cure the disease. Mitochondrial dysfunction was found to stimulate releasing of reactive oxyg...