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We proposed an in vitro/in vivo/in silico method for evaluating the clinical performance of matrix type transdermal therapeutic systems (TTSs). This method is based on the following four approaches: (1) drug release experiment, (2) in vitro penetration experiment using excised hairless mouse skin, (3) clinical pharmacokinetic study, and (4) mathematical model for evaluating the pharmacokinetic ...

Text To Speech synthesis (TTS) is an online application to convert the text written in language to speech. This application helps user to type text and as output it gets the speech. The text inputted may be written by the operator or it may be scanned paper that is converted to speech. Though the user gets its output but still conversion of text to speech is not an easy task. It involves a grea...

Text-to-speech (TTS) systems for many widely spoken languages have been developed and evolved over the last few decades. Such systems are being used in many different fields. Since these TTS systems have differences in the perceived sound quality, many speech quality test methods have been proposed to compare and evaluate their performance. Test materials for these tests, however, are language ...

This paper describes a text-to-speech (TTS) system developed at the Nagoya Institute of Technology (NITech) for the Blizzard Challenge 2017. In the challenge, about seven hours of highly expressive speech data from English children’s audiobooks were provided as training data. For this challenge, we redesigned linguistic features for statistical parametric speech synthesis based on audiobooks. F...

C lonidine is an imidazoline derivative with antihypertensive properties. Its mode of action is complex and is as yet not fully understood. Some datal-‘j indicate that an action on the central nervous system, predominantly at bulbar and diencephalic levels, causes a decreased sympathetic outflow to the cardiovascular system. Other studies’ show a direct peripheral effect as well. Since the intr...

Background Discontinuities It is fair to say that L&H’s (now Scansoft’s) RealSpeak and AT&T’s NextGen are two of the most natural sounding unit selection systems. The transitions between connected units sometimes contain discontinuities, thus creating one of the greatest problems concerning the output in these kinds of systems. The discontinuities are often perceived as ‘jumps’, i.e. a disturba...

The design of robust new interfaces that process conversational speech is a challenging research direction largely because users’ spoken language is so variable, which is especially true of children. The present research explored whether children’s response latencies before initiating a conversational turn converge with those heard in the text-to-speech (TTS) of a computer partner. A study was ...

ion of the a-proton. The rate constant for the converkz sion of Intermediate 1 to Intermediate II with [a-Hlserine as Therefore, /L.~ = kZ = 3.17 s-1. substrate which we have obtained from stopped flow absorption For [a-Dlserine, kobs = 2.74 s-l = kz + kmz; kLJkz = 3. measurements (kobs = 6.3 s-l) is about 2 times higher than the Therefore, k-2 = 3 kt; k-z = 2.05 s-1; and kp = 0.685 s-1. rate c...

The title compound tetraphenylborate salt of clonidine (Catapres®), 2-(2,6-dichlorophenylamino)-2-imidazoline (3), was prepared in 76 % yield by the reaction hydrochloride (clonidine hydrochloride) (1) with sodium (2) deionized water through anion exchange at ambient temperature. structure borate characterized UV, thermal analysis, mass and NMR analyses. White crystals (3) suitable for an X-ray...