Background: The relationship between the high activity of aldose reductase (AR) and diabetic cataract formation has been previously investigated. The purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (STZ)-induced diabetic cataract in rats.Methods: 34 adult healthy male Sprague-Dawely rats were divided into four groups. Diabetic control and diabe...

OBJECTIVE To examine the association between vitamin C and cataract in the Indian setting. DESIGN Population-based cross-sectional analytic study. PARTICIPANTS A total of 5638 people aged ≥60 years. METHODS Enumeration of randomly sampled villages in 2 areas of north and south India to identify people aged ≥60 years. Participants were interviewed for socioeconomic and lifestyle factors (t...

PURPOSE To clarify the pathogenesis of atopic cataract, especially to determine if there is any relationship between autoimmunity and atopic cataract. METHODS We investigated the lens epithelia obtained at surgery from 12 patients (12 eyes) with atopic cataract: from 8 patients (8 eyes) with nonatopic cataract (5 with senile cataract, 2 with juvenile cataract, and one with secondary cataract ...

AIM To evaluate factors associated with the development of strabismus after cataract extraction and primary intraocular lens implantation. METHODS The medical records of 122 patients, aged 1.5mo to 9y, who had undergone cataract extraction with primary intraocular lens implantation between January 1993 and August 2011 were reviewed. Fourteen patients (17 eyes) with strabismus before cataract ...

PURPOSE Diabetic cataract is one of the major eye complications of diabetes. It was reported that cataract occurs two to five times more frequently in patients with diabetes compared with those with no diabetes. The purpose of this study was to identify genetic contributors of diabetic cataract based on a genome-wide association approach using a well-defined Scottish diabetic cohort. METHODS ...

PURPOSE To present the cataract surgery practice pattern among the ophthalmic surgeons in hospitals managed by the Ministry of Health (MOH) in Malaysia. DESIGN Secondary data analysis on Malaysian Cataract Surgery Registry (CSR). METHODS The Malaysian CSR collected data on cataract surgeries done at all the ophthalmology departments in MOH from year 2002 to 2004 (paper-based) and 2007 to 20...

Purpose: To determine the incidence and determinants of intraoperative complications of cataract surgeries performed in Iran during 2000 to 2005 Methods: The Iranian Cataract Surgery Survey (ICSS) is a retrospective study in which random sampling was done from selected centers. One week per season between 2000 and 2005 was assigned to each center and records of cataract surgeries performed duri...

PURPOSE To estimate prevalence and number of people visually impaired or blind due to cataract. METHODS Based on the Global Burden of Diseases Study 2010 and ongoing literature research, we examined how many people were affected by moderate to severe vision impairment (MSVI; presenting visual acuity <6/18, ≥3/60) and blindness (presenting visual acuity <3/60) due to cataract. RESULTS In 201...

The main causes of infantile cataract are genetic, metabolic disorders, prematurity and intrauterine infections. Other causes of childhood cataract in older children include trauma, drug-induced cataract, radiation therapy and laser therapy for ROP. Trauma is one of the commonest cause of unilateral cataract in the developing countries. Bilateral cataracts occur commonly due to the long-term us...

A variety of systemic drugs including corticosteroids, amiodarone and antipsychotics have been known to cause cataract formation. Typical antipsychotics such as chlorpromazine have been reported to cause cataract formation in varying rates ranging from 22% to 80%. Cataract as an adverse effect resulting from the long term use of atypical antipsychotic has rarely been mentioned in literature, an...