BACKGROUND Chemokines play an important role in atherogenesis and in ischemic injury and repair; however, prospective data on individual chemokines in unstable angina pectoris (UAP) are scarce. Therefore, we assessed chemokine patterns in a prospective cohort of patients with UAP. METHODS AND RESULTS Plasma samples of 54 patients with Braunwald class IIIB UAP were examined at baseline for 11 ...

Systemic sclerosis (SSc) is an intractable autoimmune disease characterized by multiple organ fibrosis and vasculopathy. Recently, CCL5 has caught much attention in tumor angiogenesis internal fibrosis. In this study, we investigated the potential role of dermal vasculopathy related to SSc. Since constitutive downregulation transcription factor FLI1 been implicated SSc development, used Fli1+/-...

background: atrial fibrillation (af) is the most common cardiac arrhythmia and an independent risk factor for stroke among the elderly. a role for inflammation in the atrial remodeling as well as development and recurrence of af is known. objective: to compare il-17a between patients with different types of af and healthy individuals. methods: il-17a was measured in sera of 112 patients and 107...

Thromb Haemost 2007; 98: 917–918 In this issue of Thrombosis and Haemostasis, Sachais et al. demonstrate a critical role for platelet factor 4 (CXCL4) in the development of atherosclerosis (1). In two mouse models, CXCL4 deficiency induced by gene targeting and homologous recombination resulted in reduction of atherosclerotic lesion size without affecting platelet activation or changing cholest...

Background: Atrial Fibrillation (AF) is the most common cardiac arrhythmia and an independent risk factor for stroke among the elderly. A role for inflammation in the atrial remodeling as well as development and recurrence of AF is known. Objective: To compare IL-17A between patients with different types of AF and healthy individuals. Methods: IL-17A was measured in sera of 112 patients and 107...

background: acute myocardial infarction (ami) is the leading cause of disability and death in iran and many other countries. objective: to investigate the prognostic value of ccl5 and ccl18 in patients with acute myocardial ischemia. methods: in this cohort study we recruited and followed 50 patients with acute anterior myocardial infarction (aami) for developing cardiovascular accidents in a 6...

BACKGROUND Type-1 diabetes (T1D) is defined as a heterogeneous autoimmune disease. Immune system related factors are important in the pathogenesis of T1D. Chemokines are important factors in the pathogenesis of several autoimmune diseases, including T1D. They are potent chemotactic cytokines with various functions such as maturation, trafficking of leukocytes, angiogenesis, and homing of stem c...

Airway and systemic inflammation are features of chronic obstructive pulmonary disease (COPD), and there is growing interest in clarifying the inflammatory processes. Strenuous exercise induces an intensified systemic inflammatory response in patients with COPD, but no study has investigated the airway inflammatory and anti-inflammatory responses to exercise. Twenty steroid-naïve, ex-smokers wi...

INTRODUCTION The aim of this study was to evaluate changes in expression of soluble biomarkers tumor factor growth-β1 (TGF-β1), CCL5/RANTES, and sFas/Apo-1 in the urine of patients undergoing ureteropyeloplasty for ureteropelvic junction (UPJ) obstruction. These factors are connected with different processes ongoing in the obstructive uropathy. If their urine concentrations correlate with AP di...

BACKGROUND The aging kidney is marked by a chronic inflammation, which may exacerbate the progression of renal dysfunction, as well as increase the susceptibility to acute injury. The identification of strategies to alleviate inflammation may have translational impact to attenuate kidney disease. METHODS We tested the potential of ashwaganda, sutherlandia and elderberry on tumor necrosis fact...