background: there is evidence that mesangial cell structural changes contribute to the pathogenesis of diabetic nephropathy. to gain better insight into the mechanisms responsible for this issue, present study focused on effect of cord blood mononuclear cells (mncs) derived cd133 positive cells on mesangial cell structure and function. materials and methods: the animals were randomly divided in...

BACKGROUND CD133 is a cell surface marker of haematopoietic stem and progenitor cells. Leukaemia inhibitory factor (LIF), sustains proliferation and not differentiation of embryonic stem cells. We used CD133 to purify adult human retinal cells and aimed to determine what effect LIF had on these cultures and whether they still had the ability to generate neurospheres. METHODS Retinal cell susp...

CD133 is a pivotal marker of cancer stem cells (CSCs), which is involved in tumorigenesis and cancer progression. Recent studies have identified CD133 to be a prognostic factor for cancer rested with its expression and genetic variants. Here, we hypothesized that the single nuclear polymorphisms (SNPs) in CD133 may be associated with lung cancer risk and prognosis. Based on three independent ca...

Introduction/Background Ovarian cancer is a one of the primary cause cancer-related death in women. The majority ovarian had metastasized at time diagnosis, since its signs and symptoms are generally silent. Cancer stem cells immune evasion thought to play significant role metastatic process. CD133, CD47, PD-L1 proteins important proliferation metastasis process, which involve system a...

AIM: Colon cancer is one of the main health problems worldwide. Cancer stem cells (CSCs) are referred to as tumor-initiating involved in tumor heterogeneity and dormancy. CSCs can cause drug resistance, metastasis, recurrence primary metastatic cancers. The interactions survival trends colon with other may be an alternative route for effective treatment. In our study, we aimed evaluate effects ...

In the present study, we investigated the prognostic roles of the O6-methylguanine-DNA methyltransferase (MGMT) gene methylation status, the protein profiles of MGMT, and the glioma stem cell (GSC) marker CD133 in malignant glioma resistance to radiotherapy. The proliferation of glioma cells was assessed using a clonogenic survival assay and flow cytometry. CD133 expression was assessed in SHG-...

Recent advances in cancer stem cell biology have shown that cancer stem-like cells with epithelial-mesenchymal transition (EMT) phenotypes are more aggressive and cause relapse; however, absence of a specific marker to isolate these EMT stem-like cells hampers research in this direction. Cell surface markers have been identified for isolating cancer stem-like cells, but none has been identified...

Lung cancer is one of the most common cancers in world and a leading cause death. Cancer stem cells (CSCs) are responsible for tumor initiation. CSCs features include self-renewal capacity, differentiation, high invasion-migration, resistance to chemotherapy. characterized by specific surface markers. CD133 widely used as marker many cancers, including lung cancer. CD133-positive an important b...

Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated. One of the conflicts with this model is that cancer stem cells have been described to lack androgen receptor (AR) expression, which is of established importance in prostate cancer initiation and progression. We re-examined the expr...