نتایج جستجو برای: cd4 cd25 foxp3

تعداد نتایج: 66819  

Abbas Ghaderi, Abdol-Rasoul Talei Ahmad Hosseini Mahboobeh Razmkhah Mohammad Taghi Imani Nadieh Abedi

Background: Adipose derived stem cells (ASCs) provoke the accumulation and expansion of regulatory T cells, leading to the modulation of immune responses in tumor microenvironment. Objective: To assess the effect of tumoral ASCs on the trend of regulatory T cells differentiation. Methods: Peripheral blood naïve CD4+ T cells were co-cultured with ASCs derived from breast cancer or normal breast ...

Ebrahim Kouchaki Hassan Nikoueinejad, Hossein Akbari, Mahdi Salehi Mohammad Reza Sharif

Objective(s): Regulatory T cells, including CD4+CD25+Fox3+ and CD8+CD28- cells play an important role in regulating the balance between immunity and tolerance. Since multiple sclerosis is an inflammatory autoimmune disease, regulatory T cells are considered to be involved in its pathogenesis. In this study, we investigated the circulatory numbers of the two mentioned types of regulatory T cells...

Ali Ganji, Ehsanollah Ghaznavi-Rad, Ghasem Mosayebi, Khadije khosravi, Nader Zarinfar,

Background:   Brucellosis is one of the most common chronic diseases, with widespread distribution. In spite of cell-mediated immunity (CMI) modulated mainly via activated T-helper type 1 (Th1) cells, brucellosis can advance to chronic disease in about 10-30% of cases. Regulatory T cells (Treg cells) are involved the immune response to brucellosis; however, their role, particularly in...

Journal: :iranian journal of immunology 0
mahboobeh razmkhah shiraz institute for cancer research nadieh abedi shiraz institute for cancer research ahmad hosseini shiraz institute for cancer research mohammad taghi imani department of plastic surgery abdol-rasoul talei department of surgery abbas ghaderi shiraz institute for cancer research

background: adipose derived stem cells (ascs) provoke the accumulation and expansion of regulatory t cells, leading to the modulation of immune responses in tumor microenvironment. objective: to assess the effect of tumoral ascs on the trend of regulatory t cells differentiation. methods: peripheral blood naïve cd4+ t cells were co-cultured with ascs derived from breast cancer or normal breast ...

Ahmad Massoud Ali Akbar Amirzargar, Ali Rabbani Arya Sotoudeh Asadollah Rajab Babak Aghili Bagher Larijani Sara Assadiasl

Background: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. Autoimmune diseases may develop as a consequence of altered balance between regulatory (Tregs) and autoreactive T cells. Objectives: To evaluate Treg cells frequency and suppressive function in the peripheral blood of newly diagnosed T1D patients in compari...

Journal: :BMJ 2022

Human natural regulatory CD4+ T cells comprise 5–10% of peripheral CD4+T cells. They constitutively express the IL-2R??chain (CD25) and nuclear transcription Foxp3. These are heterogeneous contain discrete subsets with distinct phenotypes functions. Studies in mice report that LAG-3 has a complex role cell homeostasis is expressed CD4+CD25+ In this st...

Journal: :reports of biochemistry and molecular biology 0
nader zarinfar tel: +988614173502; fax: +988614173526 ali ganji department of immunology, molecular and medicine research center, school of medicine, arak university of medical sciences, arak, iran. ghasem mosayebi department of immunology, molecular and medicine research center, school of medicine, arak university of medical sciences, arak, iran. ehsanollah ghaznavi-rad molecular and medicine research center, arak university of medical sciences, arak, iran. khadije khosravi department of immunology, molecular and medicine research center, school of medicine, arak university of medical sciences, arak, iran.

background:   brucellosis is one of the most common chronic diseases, with widespread distribution. in spite of cell-mediated immunity (cmi) modulated mainly via activated t-helper type 1 (th1) cells, brucellosis can advance to chronic disease in about 10-30% of cases. regulatory t cells (treg cells) are involved the immune response to brucellosis; however, their role, particularly in the chang...

Alamtaj Samsami Dehaghani, Mahboobeh Hamedi-Shahraki Manoochehr Rasouli Mohammadreza Haghshenas Nasrollah Erfani, Somayeh Rezaeifard

Background: Ovarian cancer is the fifth leading cause of death from malignancy in women. CD4 +CD25+FoxP3+ regulatory T (Treg) cells are a subset of T lymphocytes with great inhibitory impact on immune response. Objectives: To investigate the percentage of CD4 +CD25+FoxP3+ regulatory T cells in the peripheral blood of the Iranian patients with epithelial ovarian cancer compared to healthy women ...

Journal: :iranian journal of basic medical sciences 0
ebrahim kouchaki department of neurology, kashan university of medical sciences, kashan, iran mahdi salehi student research committee, kashan university of medical sciences, kashan, iran mohammad reza sharif department of pediatrics, kashan university of medical sciences, kashan, iran hassan nikoueinejad nephrology and urology research center, baqiyatallah university of medical sciences, tehran, iran hossein akbari trauma research center, kashan university of medical sciences, kashan, iran

objective(s): regulatory t cells, including cd4+cd25+fox3+ and cd8+cd28- cells play an important role in regulating the balance between immunity and tolerance. since multiple sclerosis is an inflammatory autoimmune disease, regulatory t cells are considered to be involved in its pathogenesis. in this study, we investigated the circulatory numbers of the two mentioned types of regulatory t cells...

2009
Hua-xia Yang Wen Zhang Li-dan Zhao Yang Li Feng-chun Zhang Fu-lin Tang Wei He Xuan Zhang

INTRODUCTION Our previous study has reported that, in patients with untreated new-onset lupus (UNOL), there was an abnormal increase in the number of CD4+CD25-Foxp3+ T cells that correlated with disease activity and significantly decreased after treatment. However, little is known about the nature of this cell entity. The aim of this study was to explore the nature of abnormally increased CD4+C...

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