STING signaling induces interferon-b production by intratumoral dendritic cells (DCs), driving T cell priming within the tumor microenvironment. However, the impact of antigen-specific tolerance on this process is not well studied. We therefore examined the efficacy of in situ tumor delivery of a potent STING-activating CDN ligand (ML-RR-S2 CDA) in both non-tolerant parental FVB/N and the immun...

The objective of the present study was to investigate the biochemical pharmacology of 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine (CAFdA)--a fluorinated analogue of cladribine [2-chloro-2'-deoxyadenosine, Leustatin (CdA)] with improved acid and metabolic stability--in human leukemic cell lines and in mononuclear cells isolated from patients with chronic lymphocytic leukemia (CLL) and acute mye...

Soil organic carbon (SOC) plays a key role in soil fertility, hydrology, contaminants control and acts as a sink or source of terrestrial carbon content that can affect the concentration of atmospheric CO2. SOC supports the sustainability and quality of ecosystems, especially in semi-arid region. This study was conducted to determine relative importance of 13 different exploratory climatic, soi...

PURPOSE We tested the hypotheses that the mismatch between the clinical disc margin (CDM) and Bruch's membrane opening (BMO) is a function of BMO area (BMOA) and is affected by the presence of glaucoma. METHODS A total of 45 normal eyes (45 subjects) and 53 glaucomatous eyes (53 patients) were enrolled and underwent radial optic nerve head (ONH) imaging with spectral domain optical coherence ...

Computation Decomposition and Alignment (CDA) is a new loop transformation framework that extends the linear loop transformation framework and the more recently proposed Computation Alignment frameworks by linearly transforming computations at the granularity of subexpressions. It can be applied to achieve a number of optimization objectives, including the removal of data alignment constraints,...

Plackett-Burman design and Box-Behnken response surface methodology (RSM) was employed to optimize the medium components for the chitin deacetylase (CDA) activity from Bacillus amyloliquefaciens Z7. Plackett-Burman design was applied to determine the specific medium components affecting CDA activity and found that starch, chitin and MgSO4 were critical in augmenting CDA activity. These signific...

We contribute to the study of the optical properties of high-permittivity nanostructures deposited on surfaces. We present what we believe is a new computational technique derived from the coupled-dipole approximation (CDA), which can accommodate high-permittivity scatterers. The discretized CDA equations are reformulated by use of the sampling theory to overcome different sources of inaccuracy...

Gode & Sunder's (1993) results from using \zerointelligence" (zi) traders, that act randomly within a continuous double-auction (cda) market, appear to imply that human-like convergence to the theoretical equilibrium price in such markets is determined more by market structure than by the intelligence of the traders in that market. This paper presents a mathematical analysis that predicts serio...

The critical study of political discourse has up until very recently rested solely within the domain of the social sciences. Working within a linguistics framework, Critical Discourse Analysis (CDA), in particular Fairclough (Fairclough 1989, 1995a, 1995b, 2001; Fairclough and Wodak 1997), has been heavily influenced by Foucault. 2 The linguistic theory that CDA and critical linguistics especia...