Background: Carcinoembryonic antigen cell adhesion molecule (CEACAM) family members 5 and 6 are tumor-associated antigens frequently upregulated in epithelial cancers, including pancreatic ductal adenocarcinoma (PDAC) colorectal cancer (CRC), where they contribute to invasion, metastasis, survival, resistance chemotherapy, immune escape. CT109 is a novel antibody with dual specificity for both ...

Spheroids cultured directly from tumours can better reflect in vivo tumour characteristics than two-dimensional monolayer culture or three-dimensional culture of established cell lines. In this study, we generated antibodies by directly immunizing mice with primary-cultured living spheroids from human colorectal cancer. We performed phenotypic screening via recognition of the surface of the sph...

BACKGROUND The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung. They play a role in innate and adaptive immunity and are targets for various bacterial and viral adhesins. Two pathogens that colonize the normally sterile lower respiratory tract in patients with chronic obstructive pulmo...

We refer to the recent publication by Nakano and co-workers in Disease Models & Mechanisms (Nakano et al., 2016). This report claims that the Helicobacter pylori vacuolating cytotoxin (VacA) is the crucial factor inducing the activation of the host cell kinase for translocated CagA, Src, via a mechanism involving the receptor phosphatase RPTP-α using the human duodenum carcinoma cell line AZ-52...

Neisseria gonorrhoeae and N. meningitidis are obligate human pathogens of medical importance which are highly related at the genomic level and have a conserved array of pathogenicity determinants (Virji, 2009). N. meningitidis resides in the human nasopharynx and is the causative agent of transmissible meningitis and septic shock (Stephens et al., 2007). N. gonorrhoeae is a resident of the urog...

We refer to the recent publication by Nakano and co-workers in Disease Models & Mechanisms (Nakano et al., 2016). This report claims that the Helicobacter pylori vacuolating cytotoxin (VacA) is the crucial factor inducing the activation of the host cell kinase for translocated CagA, Src, via a mechanism involving the receptor phosphatase RPTP-α using the human duodenum carcinoma cell line AZ-52...