A simple, sensitive and economical spectrophotometric method was developed for the determination of cefixime trihydrate in pharmaceutical formulations. This method is based on the formation of pink colored chromogen complex by the reaction of drug with ferric chloride and 2, 2 bipyridyl, which absorbs maximally at 520 nm. Beer’s law is obeyed at a concentration range of 110 mcg/ml for method. T...

Using a real-time PCR assay specific for a mosaic penA allele that has been associated with oral cephalosporin resistance in Asia, 54 available Neisseria gonorrhoeae isolates collected in San Francisco, CA, from January to October 2008 were analyzed. Five isolates tested positive for the mosaic penA gene by real-time PCR. DNA sequencing revealed two mosaic penA alleles (SF-A and SF-B). Isolates...

Madam, cetirizine hydrochloride, an antihistamine, is the active constituent of Zyrtec® that functions as competitive peripheral H1 receptor inhibitor.1 Cetirizine is known to have reduced blood-brain barrier penetration due to its larger mass, lipophobic properties and increased attraction for peripheral H1 receptors. Oculogyric crisis is a neurologic impairment defined by bilateral dystonic, ...

Of six new oral cephalosporins, cefixime and cefpodoxime were the most active (MIC for 90% of isolates tested [MIC90], 16 micrograms/ml) against Bordetella pertussis, followed by cefetamet, cefprozil, and loracarbef (LY163892) (MIC90, 64 micrograms/ml) and ceftibuten (MIC90, 128 micrograms/ml). Against Bordetella parapertussis, loracarbef was more active (MIC90, 32 micrograms/ml) than the other...

A beta-lactamase prevalence of 23% was found among 1,730 Haemophilus influenzae isolates. Ampicillin susceptibility was 70%, and 12% of beta-lactamase-negative strains presented diminished susceptibility to ampicillin (BLNAR phenotype). Susceptibility of 90% was found for cefaclor and clarithromycin, whereas it was nearly 100% for cefotaxime, cefixime, azithromycin, and cefuroxime. Ciprofloxaci...

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In order to evaluate clinical and bacteriological efficacy of Cefpodoxime Proxetil (CP) in typhoid fever in comparison to cefixime (CF), we assessed 140 children with suspected typhoid fever. Fulfilling inclusion criteria finally 40 culture confirmed typhoid fever were allocated in randomized double blind clinical trial (RCT) to receive therapy with either oral CP (16 mg/kg/day, n = 21) or oral...

BACKGROUND Patients with community-acquired urinary tract infections (UTIs) frequently present to healthcare facilities in South Africa (SA). AIM To provide information on UTI aetiology and antimicrobial susceptibility of pathogens. METHODS We recruited women with UTI-related symptoms, who tested positive for ≥2 urine dipstick criteria (proteinuria, blood, leucocytes or nitrites) at 1 publi...