Results from the European gonococcal antimicrobial surveillance programme (Euro-GASP) show that the percentage of isolates with decreased susceptibility to the recommended drug for treatment of gonorrhoea (cefixime) rose from 4% in 2009 to 9% in 2010. Decreased susceptibility was detected in 17 countries in 2010, seven more than in the previous year. At the same time, the susceptibility to the ...

Cefixime is a third-generation cephalosporin antibiotic with poor solubility and permeability. The aim was to compared between Dry Grinding (DG) Liquid-Assisted (LAG) methods formed cocrystal of cefixime nicotinamide. Cocrystal prepared in 1:1 molar ratio characterizated by differential scanning calorimetry (DSC), fourier transform infra-red (FTIR), electron microscopy (SEM), x-ray diffraction ...

This double-blind randomized study compared 3-day regimens of cefixime (400 mg once daily) and ofloxacin (200 mg twice a day) in the treatment of urinary tract infections in women. The respective clinical cure rates for the two groups of women were 89 and 92% after 7 days and 81 and 84% after 4 weeks. The respective microbiological cure rates (free of bacteriuria) for the two groups of women we...

The aim of this study was to determine the toxicity cefixime in inlet solution and effluent treated with sono-electro-Fenton process using standard strains microorganisms. This research performed as an experimental study, which conducted on a laboratory scale. Escherichia coli (gram-negative) Staphylococcus aureus (gram-positive) were used for bioassay. First, stock 1000 mg/L containing Cefixim...

A sensitive, accurate, and easy indirect spectrophotometric method was developed for the determination of cefixime in its pure form pharmaceutical preparation (capsules). The depended on oxidation mixture medicinal compound by oxidizing agent N-Bromo succinimide, followed addition reagent hydralazine. brown complex obtained absorption measured at 360 nm cefixime, molar absorbance 2038.6 liters....

Introduction: The existence of pharmaceuticals in aquatic ecosystem, their persistence and possible effects on living organisms and inefficient systems in removal of these compounds from water and wastewater are a growing concern. In this research, the UV/TiO2 photocatalytic degradation of Cefixime was investigated so as to identify if this method was efficient for removal of Cefixime or not. ...

objective(s):cefixime (cfx), is a semi-synthetic third-generation oral cephalosporin antibiotic that is prescribed for the treatment of susceptible infections. there are some procedures for the determination of cfx in pharmaceutical formulations and biological samples. herein a spectrofluorimetric method was proposed for cfx determination based on the fluorescence quenching of terbium-danofloxa...

BACKGROUND Gonorrhoea has been among the easiest infections to cure with antibiotics. Nevertheless, emerging resistance has driven repeated treatment shifts. Decreased cephalosporin susceptibility is now being reported. We examined cephalosporin MIC trends for Neisseria gonorrhoeae in the UK and undertook pharmacodynamic analyses to predict efficacy against strains with raised MICs. METHODS N...

BACKGROUND Surveillance of Neisseria gonorrhoeae antimicrobial susceptibility in Europe is performed through the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP), which additionally provides data to inform the European gonorrhoea treatment guideline; currently recommending ceftriaxone 500 mg plus azithromycin 2 g as first-line therapy. We present antimicrobial susceptibility...