Objective(s): Juglone is isolated from many species of the Juglandaceae family and used as an anti-viral, anti-bacterial, and anti-tumor therapeutic. Here, we evaluated juglone-induced antitumor effect in ovarian cancer SKOV3 cells. Materials and Methods: MTT assay was performed to examine juglone anti-proliferative effect. Cell cycle and apoptosis were studied using flow cytometry in juglone-t...

Objective(s):Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore, we evaluated the effects of novel approaches including siRNA directed against BCRP and targeted t...

Background: Gastric cancer is among the most common malignancies in certain parts of the world, such as northwest Iran. miRNAs are small and single-stranded noncoding RNAs with about 19-23 nucleotides. Several studies have shown that miRNAs play important roles in gastric tumorigenesis. The aim of this study was to determine the effect of miRNA-1266-5p repression on the cell survival and altera...

in many acute leukemias, normal differentiation does not occur. however, in many cell lines derived from hematologic malignancies, differentiation or programmed cell death (apoptosis) can be induced by variety of agents including: vitamin analogs, demethylating agents, cyclic amp analogs and anti-proliferative agents. to the best of our knowledge there has been not any study specifically to ana...

new approach of breast cancer therapy is developed toward combination therapy with agent that have a specific molecular target. our previous study showed that citrus aurantifolia lime peels ethanolic extract (cpe) increased the sensitivity of mcf-7 cells againts doxorubicin. this study aims to observe the mechanism of combination cpe and doxorubicin in cell cycle modulation and apoptosis on mcf...