BACKGROUND People with central obesity have an increased risk for developing the metabolic syndrome, type 2 diabetes and cardiovascular disease. However, a substantial part of obese individuals have no other cardiovascular risk factors, besides their obesity. High sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation and a predictor of type 2 diabetes and cardiovascular dis...

serotonin (5-ht), a mono-aminergic neurotransmitter is biochemically derived from tryptophan and is mainly found in gastrointestinal tract, platelets and central nervous system of animals. serotonin (5-ht) in coordination with hypothalamus plays an important role in the cns control of appetite, eating behavior, and energy balance and body weight. it has a special role in control of carbohydrate...

OBJECTIVE Recent genome-wide association studies have identified many single nucleotide polymorphisms (SNPs) associated with body mass index (BMI)/generalized obesity. In this study, we aimed to examine the associations of identified SNPs with risk of central obesity in a child population from China. METHODS We genotyped 11 SNPs (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, BDNF rs6265,...

Background. We aimed to examine the association between sedentary time and central obesity in a nationally representative sample of adult Korean men. Methods. included 1269 participants from National Health Nutrition Examination Survey. Central was defined as having waist circumference (WC) ≥90 cm. The ORs 95% CIs for were calculated using multiple logistic regression analysis. Results. mean va...

Background: Perilipins are proteins at the external level of the lipid glob in adipocytes steroid-generating cells and play a central role in lipid storage and breakdown. FTO gene is associated with Type-2 diabetes (T2D) and increased fat mass. Association of Perilipin and FTO genes polymorphism with T2D was investigated. Methods: Clinical traits in a random sample of 183 Iranian men and wom...

OBJECTIVES Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity. Although several large-scale genome-wide association studies have reported susceptibility genes for central adiposity, the effects of interactions between genes and psychosocial stress on...

BACKGROUND Cardiovascular disease is a major cause of death, and its mortality is increasing in Latin America. However, population-based data on cardiovascular disease risk factors are sparse in these countries. METHODS A total of 7524 men and women, aged 35 to 74 years old, were recruited between February 2010 and December 2011 from randomly selected samples in 4 cities (Bariloche and Marcos...

The cytoplasmic regulatory protein p62 (Sequestosome 1/A170) is known to modulate various receptor-mediated intracellular signaling pathways. p62 deficiency was shown to result in mature-onset obesity in mice, but the mechanisms underlying this abnormality remained unclear. Here we report that hyperphagia due to central leptin resistance is the cause of obesity in p62(-/-) mice. We found that t...

Objective: To determine the best index of central obesity that predicts cardiovascular risk factors (general obesity and hypertension). Methods: A cross-sectional study involving nine hundred and sixteen (443 males and 473 females) participants of a community health survey in Sagamu and Remo-North Local Government Areas of Ogun State, Nigeria. The body mass index (BMI), waist circumference (WC)...

BACKGROUND With metabolic syndrome (MS) being a major risk factor for cardiovascular disease, and central obesity being a major predisposing factor for MS, intensive research is currently being performed on cutoff values according to race and sex. Menopause is an especially significant factor in designating cutoff values for female central obesity, as menopause brings sudden bodily changes that...