The proton-coupled oligopeptide transporter (PEPT1) has been shown to mediate mucosal cell transport of di- and tripeptide, and some peptidomimetic drugs. In this study, we determined the correlation between PEPT1 protein expression and the permeability of cephalexin, a substrate of PEPT1, in human PEPT1 (hPEPT1)-overexpressed Caco-2 cells (Caco-2/hPEPT1 cells) and rat jejunum. Caco-2/hPEPT1 ce...

A method for determining amoxicillin in human plasma by ESI-LC-MS/MS and using cephalexin as an internal standard was validated. The chromatographic separation was performed in a C18 Shim-pack CLC-ODS(M) analytical column (150 mm x 4.6 mm i.d. x 5 μm), which provided satisfactory separation of amoxicillin and cephalexin peaks, with analysis time of 3.1 minutes. A yield of extraction of 96.6% fo...

Infections caused by bacteria have a significant impact on public health. Chemical synthesis of new derivatives cephalexin inked to amino acid (tryptophan or histidine) through an amide bond at the acyl side chain is achieved. This new
 approach incorporating, tryptophan and histidine into primary group cephalexin, in order provide bulky very close ?-lactam ring. chemical addition act as i...

Cefaclor is an orally absorbed cephalosporin antibiotic chemically and pharmacologically similar to cephalexin. It appears to be more active than cephalexin against susceptible strains. The in vitro sensitivity of 230 clinical bacterial isolates to cefaclor was studied. Most isolates of S. aureus, K. pneumoniae, E. coli, and indole negative Proteus species were inhibited at clinically attainabl...

Cephalexin (1) was acylated using N-acylbenzotriazoles (3a-k') derived from various carboxylic acids including aromatic, heterocyclic and N-Pg-α-amino acid to afford N-acylcephalexins in excellent yields (82%-96%). Antibacterial screening of the novel cephalosporins revealed that all targets (4a-j) retained the antibacterial activity of cephalexin against Staphylococcus aureus (ATCC 6538). N-Ni...

Boothman, R., Kerr, M. M., Marshall, M. J., and Burland, W. L. (1973). Archives of Disease in Childhood, 48, 147. Absorption and excretion of cephalexin by the newborn infant. Blood levels and urinary excretion of cephalexin were studied in newborn infants who were given 3-day courses of the antibiotic prophylactically. These infants were born to mothers with intrapartum pyrexia or with membran...

TO THE EDITOR—We read with much interest the article by Pallin et al [1], which presents the data from the double-blind, randomized, placebo-controlled trial that compared the clinical effectiveness of trimethoprim/sulfamethoxazole plus cephalexin vs cephalexin alone in treatment of cellulitis without abscess in the outpatient setting where community-associated methicillin-resistant Staphylococ...

The mechanism of action of a new orally active cephalosporin, FK027, was compared to that of cephalexin and cefaclor to elucidate its excellent antibacterial activity against Gram-negative bacteria. FK027 showed very high affinity for the penicillin-binding proteins (PBPs) 3, 1a and 1bs of Escherichia coli whereas cephalexin showed fairly high affinity for PBPs 1a, 4 and 3. The ability of FK027...

The effectiveness of cephalexin, an oral cephalosporin using a dosage equivalent to available capsular dosage forms, was studied in relation to the effectiveness of phenoxymethyl penicillin and benzathine penicillin in the treatment of 128 patients with beta-hemolytic streptococcal pharyngitis, all but six of whom had group A streptococci isolated from throat cultures. Approximately one-half, 6...

The pharmacokinetics of cefaclor and cephalexin were characterized in patients with creatinine clearances ranging from 0 to 147 ml/min. Each of 24 fasted subjects received a single 500-mg oral dose of cefaclor, and 13 of these subjects later received 500 mg of cephalexin. Serum and urine levels of the antibiotics were measured by bioassay. The serum half-lives were highly correlated with correc...