Meldrum, Kirstan K., Daniel R. Meldrum, Xianzhong Meng, Lihua Ao, and Alden H. Harken. TNF-dependent bilateral renal injury is induced by unilateral renal ischemiareperfusion. Am J Physiol Heart Circ Physiol 282: H540–H546, 2002; 10.1152/ajpheart.00072.2001.—While tumor necrosis factor (TNF)is an important mediator of renal ischemiareperfusion (I/R) injury, its role in contralateral renal injur...

Ischemia-reperfusion injury, a common complication during liver surgery where steatotic livers are more prone to the injury, may become more prevalent in the growing obese population. This study characterizes liver morphology toward understanding changes in subcellular function in steatotic livers exposed to ischemiareperfusion injury through quantitative description of fluorescein distribution...

Börjesson, Anna, Andreas Norlin, Xiangdong Wang, RolandAndersson, and Hans G. Folkesson. TNF-a stimulates alveolar liquid clearance during intestinal ischemiareperfusion in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L3–L12, 2000.—Intestinal ischemia-reperfusion commonly occurs in critically ill patients and may lead to the development of remote organ injury, frequently involving the lu...

SEE PAGE 47 A MP-activated protein kinase (AMPK) is a molecular energy sensor that is essential to the stress response in the heart (1). AMPK is activated during energy imbalance, when the ADPor AMP-toATP ratio increases. Because few proteins have adenine nucleotide binding domains, the activation of a protein kinase, which phosphorylates numerous downstream proteins, amplifies the energy stres...

Börjesson, Anna, Andreas Norlin, Xiangdong Wang, RolandAndersson, and Hans G. Folkesson. TNF-a stimulates alveolar liquid clearance during intestinal ischemiareperfusion in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L3–L12, 2000.—Intestinal ischemia-reperfusion commonly occurs in critically ill patients and may lead to the development of remote organ injury, frequently involving the lu...

Epidemiological studies show that particulate matter (PM) is the principal instigator of some adverse clinical symptoms involving cardiovascular diseases. PM exposure can increase experimental infarct size and potentiate myocardial ischemia and arrhythmias in experimental MI models such as ischemia-reperfusion (I/R) injury.The present study was aimed to evaluate the effects of particulate matte...

The incidence and severity of primary cardiac events are inversely related to the plasma concentration of high-density lipoproteins (HDLs). We investigated whether HDLs may exert a direct cardioprotection in buffer-perfused isolated rat hearts, which underwent a 20-minute low-flow ischemia followed by a 30-minute reperfusion. The administration of HDLs at physiological concentrations (0.5 and 1...

The pathophysiology of multiple disease states, including sepsis,1,2 hypertension,1 atherosclerosis,3–5 and ischemiareperfusion injury,6 is characterized by loss of the endothelial barrier function leading to the accumulation of plasma-borne proteins, tissue edema, and cell death. Importantly therapeutic strategies that inhibit loss of endothelial barrier function have been associated with stra...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 cerebral amyloid angiopathy (caa) is the most common cause of lobar intracerebral hemorrhage. repeated bleeding may be presented with vascular dementia. we have reported a 68-year-old normotensive demented patient with probable caa presented with hemiparesia, headache and vomiting. according to the experience of this case,...