The age-associated alteration in expression levels of carboxylesterases (CESs) can affect both intestinal and hepatic first-pass metabolism after oral administration of xenobiotic esters such as prodrugs. In this study, the age-related expression of CES isozymes and hydrolase activities were simultaneously investigated in liver, jejunum, and ileum from 8-, 46-, and 90-week-old rats. Rat liver e...

Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an alpha,beta-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can be classified into five major groups denominated CES1-CES5, according to the homology of the amino acid sequence...

Book review: Vesiculation and crystallization of magma: fundamentals the volcanic eruption pro-cess, by Atsushi Toramaru, 2022. Springer [Advances in Volcanology]; xxxii + 427 pages;hardcover price €149.79, paperback €149.79; eBookprice €117.69, ISBN 978-981-16-4208-1

Aims: Nosocomial pneumonia is a prevalent complication in patients admitted to intensive care units. Endotracheal suction (ES) used clean the airways of secretions under mechanical ventilation (MV). The objective this study was compare effects an open endotracheal system (OESS) versus closed (CESS) on incidence ventilator-associated (VAP).
 Study Design: Retrospective examination hospital ...

We have cloned two rearranged heavy chain variable region (VH) genes from the IgG-producing human cell line CESS. The VH gene, which is linked to the mu chain constant region (C mu) gene, has two deletions at residues 45-62 and 82A-90, the former of which corresponds closely to the second complementarity-determining region (CDR2). These results could indicate that translocation of CDR2 occurred...

In this paper we present the methodology followed in the automatic semantic annotation (argument structure and thematic roles of the verbal predicates) of the CESS-ECECAT/ESP corpus. Building from a verbal lexicon (1,482 entries) with information about the syntactic functions and their projection to arguments and thematic roles, we present a set of simple rules to automatically enrich syntactic...

The age-associated alteration in expression levels of carboxylesterases (CESs) can affect both intestinal and hepatic first-pass metabolism after oral administration xenobiotic esters such as prodrugs. In this study, the age-related CES isozymes hydrolase activities were simultaneously investigated liver, jejunum, ileum from 8-, 46-, 90-week-old rats. Rat liver expresses three major CES1 isozym...

Abstract Background Ethics are the set of moral principles that guide a person’s behaviour. Ethical issues key component healthcare and frequently arise in management hospitalized older patients. To improve decision-making reduce burden on individual hospital staff, Clinical Support Services (CESS) have been widely-integrated into care pathways internationally. However, need for CESS has receiv...