Lecithin:cholesteryl acyl transferase (LCAT), cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), and lipoprotein lipases are involved in high density lipoprotein (HDL) metabolism. We evaluated the influence of insulin sensitivity and of the TaqIB CETP gene polymorphism (B1B2) on plasma LCAT, CETP, and PLTP activities (measured with exogenous substrates) and their r...

EcoRI polymorphism within the GLI gene (chromosome 12q13.3-14.1) Source/Description: pKK36Pl contains a 1.55 kb PstI genomic fragment of GLJ cloned into the PstI site of pGEM-3 (1). Polymorphism: EcoRI identifies a two allele polymorphism (Al: 18 kb; A2: 5 kb). Frequency: Estimated from 91 individuals. Al 18 kb (0.72) A2 5kb (0 28) Chromosomal Localisation: Assigned to chromosome 12ql3.3-14.1 u...

BACKGROUND AND AIMS Several genes have been shown to individually affect plasma lipoprotein metabolism in humans. Studies on gene-gene interactions could offer more insight into how genes affect lipid metabolism and may be useful in predicting lipid concentrations. We tested for gene-gene interactions between TaqIB SNP in the cholesterol ester transfer protein (CETP) and three novel single nucl...

Alterations in lipoprotein levels are reported to be related to an increased risk of gallstones. Plasma lipid metabolism is regulated by a number of proteins that are polymorphic in the population. The present research was designed to investigate the association between the polymorphisms of these proteins and the presence of various gallbladder diseases. Restriction fragment length polymorphism...

BACKGROUND The I405V polymorphism of the cholesteryl ester transfer protein gene (CETP) has been suggested to be a protective factor conferring longevity in Ashkenazi Jews, although findings in other races are not supportive. This paper describes a case-control study and a meta-analysis conducted to derive a more precise estimation of the association between CETP 405V and longevity. METHODS W...

BACKGROUND The cholesteryl ester transfer protein (CETP) plays a central role in reverse cholesterol transport. Currently, it remains unresolved whether circulating CETP is causally associated with coronary heart disease (CHD). We aimed to investigate this causal association using CETP gene rs708272 polymorphism as an instrument in a Mendelian randomization meta-analysis. METHODS AND RESULTS ...

A number of studies have been conducted to explore the association between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism and risk of myocardial infarction (MI); however, the results are inconsistent. Therefore, we conducted this meta-analysis to clarify the issue based on all the data available.Eligible studies were retrieved by searching PubMed, Embase, Web of Science, and G...

Citation: Miller NE (2015) Cholesteryl ester transfer protein: ace of spades, queen of hearts, or the joker? Front. Pharmacol. 6:145. Plasma cholesteryl ester transfer protein (CETP) catalyzes the transfer of CEs from high-density lipoproteins (HDLs) to triglyceride-rich and low-density lipoproteins (LDLs). The hypothesis that CETP inhibition will prevent cardiovascular disease (CVD) was based ...