OBJECTIVE Estradiol (E2) regulates gene transcription by activating estrogen receptor-α and estrogen receptor-β. Many of the genes regulated by E2 via estrogen receptors are repressed, yet the molecular mechanisms that mediate E2-induced gene repression are currently unknown. We hypothesized that E2, acting through estrogen receptors, regulates expression of microRNAs (miRs) leading to repressi...

Most of the traditional recommendation algorithms are based on TF-IDF, a term-based weighting method. This paper proposes a new method for recommending news items based on the weighting of the occurrences of references to concepts, which we call Concept Frequency-Inverse Document Frequency (CFIDF). In an experimental setup we apply CF-IDF to a set of newswires in which we detect 1, 167 instance...

cystic fibrosis (cf) is an inherited disease that primarily affects the lungs and the digestive system, however, it also affects a number of other organs and systems. more than 90% of mortality of  cf patients is due to lung complications.  healthy lungs are important for a long life for people with cf, we will discuss two important topics for maintaining respiratory health. chronic use of drug...

A study using 51 wheat, 56 barley and 34 oat grain samples was conducted to investigate the feasibility of predicting the apparent metabolizable energy (AME) value of these cereals for poultry. Stepwise regression analyses were performed to evaluate the relationship of AME with starch, ether extract (EE), crude fiber (CF), soluble sugar (SS), ash and crude protein (CP) (for wheat and barley gra...

Current treatments for patients with Crohn's disease (CD) are based on recent advances in elucidating the pathophysiology of the disease. A satisfactory therapeutic strategy has not been well established. A new sphingosine 1-phosphate (S1P) receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), has been developed for immunomodulation in autoimmune diseases and organ transplantation. W...