K. Almond*, P. Bikker, M. Lomax, M. E. Symonds and A. Mostyn Academic Division of Child Health, School of Clinical Sciences, E floor East Block, University Hospital, Nottingham NG7 2UH, UK Division of Nutritional Sciences, School of Biosciences, North Lab, University of Nottingham, Sutton Bonnington Campus, Loughborough LE12 5RD, UK Schothorst Feed Research, Lelystad, The Netherlands School of ...

Newly replicated Plasmodium falciparum parasites escape from host erythrocytes through a tightly regulated process that is mediated by multiple classes of proteolytic enzymes. However, the identification of specific proteases has been challenging. We describe here a forward chemical genetic screen using a highly focused library of more than 1,200 covalent serine and cysteine protease inhibitors...

Biomaterial-based strategies to restore connectivity after lesion at the spinal cord are focused on bridging the lesion and providing an favourable substrate and a path for axonal re-growth. Following spinal cord injury (SCI) a hostile environment for neuronal cell growth is established by the activation of multiple inhibitory mechanisms that hamper regeneration to occur. Implantable scaffolds ...

2010.6 The National Institute on Alcoholism and Alcohol Abuse (NIAAA) formed a special task force to make recommendations to address the problem.7 Binge drinking has even received global attention from the World Health Organization, which convened a conference to address the topic.8 Several prominent organizations and key leaders have accepted this call to action. Mothers Against Drunk Driving ...

Since survival time is a quantitative variable, why can’t we just use the usual techniques from Table I? Before we explain the main reason why we use survival analysis, let’ us consider a simple example on the survival times (in months) for 25 lung cancer patients who all died; the timings are : 1, 5, 6, 6, 9, 10, 10, 10, 12, 12, 12, 12, 12, 13, 15, 16, 20, 24, 24, 27, 32, 34, 36, 36, 44 months...

BACKGROUND There are controversies about the most effective treatment to eradicate first growth of Pseudomonas aeruginosa (P aeruginosa) from the lower airways of patients with cystic fibrosis (CF). UK guidelines recommend oral treatment, but some advocate intravenous (IV) treatment. The objective of this study was to assess the feasibility of conducting a randomised controlled trial comparing ...

BACKGROUND/AIMS Increasing evidence has shown that miR-203 plays important role in human cancer progression. However, little is known about the function of miR-203 in osteosarcoma (OS). METHODS The expression of miR-203 in OS tissues and cell lines were examined by qRT-PCR. The biological role of miR-20 in OS cell proliferation was examined in vitro and in vivo. The targets of miR-203 were id...