Abstract Concrete Facing Rockfill Dam (CFRD) is a popular type of dam for hydropower plant due to its relatively good stability than others. However, CFRD have potential technical issue concerning seepage and leakage as it has thin impermeable layer. In this study, against was evaluated by finite element simulation. facing layer foundation were assumed undergo permeability coefficient (K) incre...

Background: Annual screening for CF-related diabetes (CFRD) is recommended from age 10 in the UK. Regular oral glucose tolerance test (OGTT) or Continuous monitoring (CGM) difficult to achieve (35% of patients ≥10 yr had CFRD 2021, UK CF Registry Data). We currently use CGM at and 14 children with clinical concerns. Objective: To evaluate modified control (GCT) children. Methods: GCT was introd...

Pulmonary insufficiency is the main cause of death in cystic fibrosis (CF). We analysed forced expiratory volume in 1 s (FEV1) data of 14,732 patients registered in the European Cystic Fibrosis Society Patient Registry (ECFSPR) database in 2007. We used linear and logistic regressions to investigate associations between FEV1 % predicted and clinical outcomes. Body mass index (BMI), chronic infe...

Increased large artery stiffness occurs in a range of inflammatory conditions indicating an ageing of the vasculature and additionally being an independent risk factor for cardiovascular events. We determined large artery parameters in adults with cystic fibrosis (CF). 50 clinically stable adult patients with CF (mean+/-sd age 28.0+/-8.2 yrs) and 26 controls matched for age, sex and body mass i...

The cystic fibrosis (CF) airway surface liquid (ASL) provides a nutrient rich environment for bacterial growth including elevated glucose, which together with defective bacterial killing due to aberrant HCO3- transport and acidic ASL, make the CF airways susceptible to colonisation by respiratory pathogens such as Pseudomonas aeruginosa. Approximately half of adults with CF have CF related diab...

In the general population, altered glucose metabolism is associated with deleterious microvascular changes, inflammatory cardiovascular disease and death. Large population studies have established clinically relevant glucose threshold levels associated with these risks. These have led to the currently accepted definitions of diabetes and oral glucose tolerance abnormalities as well as recommend...

Diabetes is a common comorbidity in cystic fibrosis (CF) that worsens prognosis. The lack of an animal model for CF-related diabetes (CFRD) has made it difficult to dissect how the onset of pancreatic pathology influences the emergence of CFRD. We evaluated the structure and function of the neonatal CF endocrine pancreas using a new CFTR-knockout ferret model. Although CF kits are born with onl...