The aim of this study was to synthesize chalcone-polyamine conjugates in order enhance bioavailability and selectivity chalcone core towards cancer cells, using polyamine-based vectors. Indeed, it is well-known that polyamine transport system upregulated tumor cells. 3′,4,4′,5′-tetramethoxychalcone selected as parent since found be an efficient anti-proliferative agent on various A series five ...

A number of novel heterocyclic chalcone derivatives can be synthesized by thermal and microwave tools. Treatment of 4-(4-Acetylamino- and/or 4-bromo-phenyl)-4-oxobut-2-enoic acids with hydrogen peroxide in alkaline medium were afforded oxirane derivatives 2. Reaction of the epoxide 2 with 2-amino-5-aryl-1,3,4-thiadiazole derivatives yielded chalcone of imidazo[2,1-b]thiadiazole derivative 4 via...

Purpose: The study was designed to investigate the effects of a novel spironolactone chalcone in the prevention of peritoneal fibrosis. Methods: Wistar rats (n = 30) were randomly assigned to 3 groups: bacteria (B), spironolactone amide treatment (S), and control (C) groups. C group received only dextran beads while S and B groups were given bacteria and dextran beads intraperitoneally, but spi...

The purpose of this paper is to investigate the inhibition effect of some Chalcone derivatives on the corrosion behavior of aluminum in 1 M phosphoric acid solutions with and without Chalcone derivatives and to investigate the influence of halide additives namely: KCl, KBr and KI on the inhibition efficiency of aluminum. For this purpose, polarization (DC) and weight loss measurements were used...

An effective method has been developed for the preparation of novel chiral chalcone derivatives under mild conditions from the easily accessible starting materials nitromethane and chalcone derivatives 2. The corresponding products were obtained in moderate yields with excellent enantioselectivities (up to 99%).

We report the first asymmetric, total synthesis of (-)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the preparation of the entire isomeric family of silybin natural products.

Chalcone derivatives are frequently found in bioactive compounds, natural products, and pharmaceuticals. In this study, we developed a KOtBu/DMF catalytic system to efficiently synthesize chalcone by isomerizing propargylic alcohols bearing aryl substituents at the 1- 3-positions. Mechanistic investigations confirmed that 1,3-hydride shift was key process for successful reaction. Our method doe...

In this study, light-emitting diodes (LEDs) used as secure, low-cost and possessing long emission wavelengths irradiation sources were applied in photopolymerization. Seven novel anthracene derivatives (noted A1-A7) proposed evaluated photosensitive systems. Three of them never synthesized before (A1, A2 A7) the other fields. Due to in-silico design molecular structure by modeling, chalcone-ant...

Hymenoclea salsola, Asteraceae, Resin Flavonoids, 2',4',6 'OH Chalcone Hymenoclea salsola (Asteraceae), a dominant shrub of the desert areas of California and Baja California, Mexico, secretes high amounts of resin on the leaf surface. Chemi­ cal analysis of the resin revealed the presence of a complex mixture of flavonoid aglycones. Among the compounds identified is the rare 2',4',6'-OH chalco...

The aim of this study was to investigate novel chalcones with potent angiogenic activities in vivo. Chalcone-based derivatives were evaluated using a transgenic zebrafish line with fluorescent vessels to real-time monitor the effect on angiogenesis. Results showed that the chalcone analogues did not possess anti-angiogenic effect on zebrafish vasculatures; instead, some of them displayed potent...