A 23-year-old man with Pelizaeus-Merzbacher disease had a novel mutation, C344A (Thr115Lys), in exon 3 of the proteolipid protein gene (PLP) His mother, heterozygous for the mutation, developed progressive personality change and a gait disorder in her mid-20s. Her MRI at age 53 showed a diffuse severe leukodystrophy. This report extends the phenotypic range of disease due to PLP gene mutations ...

Practice Effects (PE) have been gaining interest as an early marker of pathological cognitive decline among older adults, with cognitively compromised individuals exhibiting diminished or absent PE, presumably due to reduced ability to learn. However, the opposite pattern has also been observed, with MCI participants showing larger PEs than controls. In this prospective cohort study, we examine...

The current meta-analysis investigated the extent to which personality traits changed as a result of intervention, with the primary focus on clinical interventions. We identified 207 studies that had tracked changes in measures of personality traits during interventions, including true experiments and prepost change designs. Interventions were associated with marked changes in personality trait...

OBJECTIVE In light of growing debate over whether and how early life educational experiences alter late-life cognitive trajectories, this study sought to more thoroughly investigate the relationship between educational attainment and rates of late-life cognitive decline in a racially, ethnically, and educationally diverse population. METHOD Older adults (N = 3,435) in the community-based Wash...

In Scandinavia, at least 11.500 people were lobotomized in the period 1939-1983. Beside grave personality changes, the surgery caused epilepsy in 10-35% of the patients. Moreover, many died due to perioperative bleedings, convulsive status epilepticus or SUDEP. Most of the stories of these people are anonymous and their post-lobotomy lives are scarcely documented. If it was not for the fact tha...

A 21 year old male developed hallucinations, personality change and severe depression following an increase in oral propranolol administration at recommended dosage levels. The symptoms improved markedly on stopping the drug. Without provocation, the patient developed further symptoms, mainly depressive, with marked suicidal impulses. Again, this quickly settled. The case identifies the need fo...

OBJECTIVE This study evaluates longitudinal neuropsychological performance and its association with clinical symptomatology and psychosocial outcome in individuals identified as ultra high risk (UHR) for psychosis. METHODS Thirty-five UHR individuals completed neurocognitive, clinical, and social/role functioning assessments at baseline and, on average, 8.3 months later. RESULTS UHR subject...

OBJECTIVE The aims of this study were to develop models of personality change after traumatic brain injury (TBI) based on information provided by the TBI survivor and a significant other (SO), and to compare the models generated from the two different sources of information. METHODS Individuals with and without TBI and an SO were interviewed separately about their current personality. The SOs...

We show that the proper motion of the Becklin-Neugebauer (BN) object is consistent with its dynamical ejection from the ΘC binary, contrary to recent claims by Gómez et al. Continued radio observations of BN and future precise astrometric observations of ΘC with SIM and the Orion Nebula Cluster with GAIA can constrain the properties of this ejection event, with implications for theories of how ...

Computed tomography (CT) is widely used in postmortem investigations as an adjunct to the traditional autopsy in forensic medicine. To date, several studies have described postmortem CT findings as being caused by normal postmortem changes. However, on interpretation, postmortem CT findings that are seemingly due to normal postmortem changes initially, may not have been mere postmortem artifact...