During a 20-year longitudinal study of cognitive change in old age 2,342 of 5,842 participants died and 3,204 dropped out. To study cognitive change as death approaches, we grouped participants by survival, death, dropout, or dropout followed by death. Linear mixed-effects pattern-mixture models compared rates of cognitive change before death and dropout from four quadrennial administrations of...

In 2001 Brett and Baxendale reviewed cognitive change in pregnancy and concluded that although “...much has been written in an impressionistic way....at the beginning of the twenty first century considerable gaps in our knowledge remain” (pp. 339). Ten years later a clear picture describing cognitive change in women has still failed to emerge. Recent work investigating pregnancy-induced cogniti...

The Vietnam Era Twin Study of Aging (VETSA) is a longitudinal behavioral genetic study with a primary focus on cognitive and brain aging in men. It comprises a subset of over 1,200 twins from the Vietnam Era Twin Registry. Like many other studies of aging, the VETSA includes many different phenotypes, but there are some key features that distinguish it from most other behavioral genetic aging s...

A close relative of each of 42 severely head injured patients was interviewed at 5 years after injury, following initial study at 3, 6, and 12 months. Persisting severe deficits, in some cases worse than at 1 year, were primarily psychological and behavioural, although minor physical deficits, for example in vision, were also common. Relatives were under great strain; significantly more so than...

OBJECT Patients with gliomas frequently have cognitive deficits, and surgery can exacerbate these deficits. Preoperative assessment is therefore crucial in patients undergoing surgery for glioma in eloquent areas, because the proximity of functional areas increases the risk of permanent postoperative cognitive disturbances. Although pre- and postoperative language and motor function in patients...

Although older adults with Mild Cognitive Impairment (MCI) show elevated rates of conversion to dementia as a group, heterogeneity of outcomes is common at the individual level. Using data from a prospective 5-year longitudinal investigation of cognitive change in healthy older adults (N = 262, aged 64-92 years), this study addressed limitations in contemporary MCI identification procedures whi...

OBJECTIVE The current study examines the role of social contact intensity, cognitive activity, and depressive symptoms as within- and between-person mediators for the relationships between physical activity and cognitive functioning. METHOD All three types of mediators were considered simultaneously using multilevel structural equations modeling with longitudinal data. The sample consisted of...

BACKGROUND Developing measures to detect preclinical Alzheimer's Disease is vital, as prodromal stage interventions may prove more efficacious in altering the disease's trajectory. Gait changes may serve as a useful clinical heuristic that precedes cognitive decline. This study provides the first systematic investigation of gait characteristics relationship with relevant demographic, physical, ...

This paper presents our experiences of a 14 months participatory action research project in the Audit Commission, a major governmental body, responsible for auditing, inspecting and researching public service quality and efficiency throughout the territories of England and Wales. Its workforce, geographically widely dispersed, must operate in strict observance of legal regulations and policy gu...

This paper formulates in the first part some requirements for a certain sort of computational argumentation systems, namely those which are designed for a very specific purpose: to motivate reflection on one’s own thinking, and to induce cognitive change. This function of argumentation systems is important for argument-based conflict negotiations, deliberation processes, intercultural communica...