Abstract Background Ethnobotanical studies on plants and their active compounds take a great interest in traditional medicine. After pharmacological toxicological studies, there will be possibility to used therapy. This study aimed examine the vitro antioxidant cytotoxic activity of methanol extracts Arbutus andrachne L. Euphorbia rigida M.Bieb. 10, 25, 50, 75, 100 150 µg mL −1 concentrations A...

BACKGROUND Curcumin induces apoptosis and autophagy in different cancer cells. Moreover, chemical and biological experiments have evidenced that curcumin is a biologically active iron chelator and induces cytotoxicity through iron chelation. We thus hypothesized that curcumin may induce apoptosis and autophagy in castration-resistant prostate cancer (CRPC) cells through its iron-chelating prope...

BACKGROUND Baeckea frutescens is a natural remedy recorded to be used in curing various health conditions. In Peninsular Malaysia, B. frutescens is found on the mountain tops, quartz ridge and sandy coasts. To our knowledge, there is only limited published literature on B. frutescens. METHODS B. frutescens leaf crude methanol and its fractionated extracts (hexane, ethyl acetate and water) wer...

The role of epidermal growth factor in the regulation of the proteolytic and RBC cytolytic activity of the A431 cancer cell line has been evaluated using our previously described gelatin/polyacrylamide electrophoretic assay and tumor-induced RBC cytolysis assay, respectively. A431 cells maintained in 10% fetal bovine serum were actively cytolytic for RBC (release index, 53.0 +/- 2.9%), whereas ...

Polyphenols, as plant secondary metabolites, achieve strong antioxidant capacity by scavenging free radicals, chelating metals, and interacting with lipid membranes, proteins nucleic acids. The aim of the present study was examination applied extraction conditions (particle size material, solvent-to-solid ratio, solvent type, time) techniques (maceration, heat- ultrasound-assisted extractions) ...

Antioxidant activity of Feijoa sellowiana leaves and fruit peels was investigated employing various in vitro assay systems. IC50 for DPPH radical-scavenging activity was in the order: leaf aqueous extract, LW (7.25 ± 0.31) > leaf methanolic extract, LM (12.5 ± 0.34) > fruit peels aqueous extract, FW (20.25 ± 0.52) > fruit peels methanolic extract, FM (34.5.29 ± 0.44) μg ml, respectively. The ex...

AIM Catechins profile, caffeine content and antioxidant activity of different green tea and white tea samples commercialized on the Romanian market were investigated. MATERIAL AND METHODS Five green tea samples and five white tea samples commonly available on the Romanian market were processed by infusion and the lyophilisates of infusions were analyzed. Total phenolic content was determined ...

The role of the 6″-OH (ω-OH) group in the antioxidant activity of flavonoid glycosides has been largely overlooked. Herein, we selected quercitrin (quercetin-3-O-rhamnoside) and isoquercitrin (quercetin-3-O-glucoside) as model compounds to investigate the role of the 6″-OH group in several antioxidant pathways, including Fe2+-binding, hydrogen-donating (H-donating), and electron-transfer (ET). ...

In this study, a series of di-O-caffeoylquinic acids (di-COQs) were systematically investigated for their antioxidant and cytoprotective effects towards •OH-damaged bone marrow-derived mesenchymal stem cells (bmMSCs). Five di-COQs were measured using a set of antioxidant assays. The results show that adjacent 4,5-Di-O-caffeoylquinic acid (4,5-COQ) and 3,4-di-O-caffeoylquinic acid (3,4-COQ) alwa...