Objective: To date, numerous studies have been conducted to search for reasons for chemoresistance and differences in survival rates of patients receiving chemotherapy. We have sought to identify differentially expressed genes (DEGs) between predicted chemotherapy resistance and sensitive phenotypes by a network as well as gene enrichment approach. Methods: Functional modules were explored with...

Background and Aim: Hairy enhancer of split-1 (HES1) is a downstream transcriptional factor of Notch signaling pathway, which was found to be related to chemoresistance. This study was aimed to investigate the role of HES1 in chemoresistance of colorectal cancer (CRC). Methods: Tissue microarray was used to analyze the clinical significance of HES1 in radical resected (R0) stage II/III CRC pati...

The nuclear factor (NF)-kappaB system is a promising anticancer target due to its role in oncogenesis and chemoresistance in preclinical models. To provide evidence in a clinical setting on the role of NF-kappaB in breast cancer, we aimed to study the value of basal NF-kappaB/p65 in predicting resistance to neoadjuvant chemotherapy, and to characterise the pharmacodynamic changes in NF-kappaB/p...

A critical challenge for chemotherapy is the development of chemoresistance in breast cancer. However, the underlying mechanisms and validated predictors remain unclear. Extracellular vesicles (EVs) have gained attention as potential means for cancer cells to share intracellular contents. In adriamycin-resistant human breast cancer cells (MCF-7/ADM), we analyzed the role of transient receptor p...

Chemoresistance is a complex mechanism, involving various biological pathways. Also, chemoresistance is a major cause of cancer treatment failure. Cancer stem cell (CSC) in solid cancer has recently identified, but its role in solid organ tumour is not clearly documented. However, research data supported that CSC may involve in carcinogenesis, invasion and metastasis, as well as resistance to v...

BACKGROUND Breast cancer is the most commonly diagnosed cancer in women, and has become the second leading cause of cancer death among women worldwide. Chemoresistance has become an important problem in breast cancer clinics. The identification of new mechanisms affecting chemosensitivity is of great clinical value for the treatment of breast cancer. METHODS The expression levels of chemoresi...

Although current chemotherapy regimens are effective at eliminating the bulk of acute myeloid leukemia (AML) blasts, the disease relapses in the majority of patients. Whether relapse arises through the selection of a relatively rare subpopulation of cells present at diagnosis having specific characteristics that facilitate chemoresistance or through the induction of changes required to render t...

Hepatocellular cancers (HCC) are highly resistant to chemotherapy. TGFβ has been associated with chemoresistance in some human cancers but the mechanisms involved are unknown. We explored how TGFβ might contribute to altered responses to therapy by assessing the involvement and mechanistic contribution of extracellular vesicle long non-coding RNA (lncRNA) in mediating TGFβ-dependent chemoresist...

Effective cancer therapy requires identification of signaling networks and investigating their potential role in proliferation invasion cells. Among molecular pathways, signal transducer activator transcription 3 (STAT3) has been importance due to its involvement promoting proliferation, cells, mediating chemoresistance. In the present review, our aim is reveal STAT3 pathway bladder (BC), as on...

Tongue squamous cell carcinoma (TSCC) is one of the most common head and neck cancers. Cisplatin is effective as a single agent or in combination with other drugs for the treatment of TSCC. Treatment with cisplatin-based chemotherapy has been found to improve the prognosis of patients with TSCC. However, one of the most important clinical issues of cisplatin-based TSCC chemotherapy is the intri...