نتایج جستجو برای: chitosan

تعداد نتایج: 17212  

2002
Tugce Dastan Kadir Turan

Purpose: Chitosan has a high potential for transferring DNA molecules into mammalian cells because of its cationic properties. In the present study, we have investigated DNA encapsulation efficiency and loading capacity of chitosan microparticles prepared in different conditions, as well as in vitro DNA release from microparticles, and transfection of different cell lines with chitosan-DNA micr...

Journal: :European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2014
Zahra Merchant Kevin M G Taylor Paul Stapleton Sana A Razak Nitesh Kunda Iman Alfagih Khalid Sheikh Imran Y Saleem Satyanarayana Somavarapu

The potential of amphiphilic chitosan formed by grafting octanoyl chains on the chitosan backbone for pulmonary delivery of levofloxacin has been studied. The success of polymer synthesis was confirmed using FT-IR and NMR, whilst antimicrobial activity was assessed against Pseudomonas aeruginosa. Highly dispersible dry powders for delivery as aerosols were prepared with different amounts of chi...

Journal: :Biomacromolecules 2008
Marc Lavertu Dominic Filion Michael D Buschmann

Recently, chitosan dissolved in solutions containing glycerol phosphate (GP) were found to undergo a sol-gel transition when heated and the proposed gelling mechanism was based on increasing hydrophobic interactions with temperature. Subsequently, an investigation of ionization and precipitation behavior of chitosan, including dependencies on temperature, added salt, and fraction of deacetylate...

Journal: :Arthritis Research & Therapy 2009
Pascale Simard Hugo Galarneau Sébastien Marois Daniel Rusu Caroline D Hoemann Patrice E Poubelle Hani El-Gabalawy Maria JG Fernandes

INTRODUCTION Osteoarthritis is characterized by the progressive destruction of cartilage in the articular joints. Novel therapies that promote resurfacing of exposed bone in focal areas are of interest in osteoarthritis because they may delay the progression of this disabling disease in patients who develop focal lesions. Recently, the addition of 80% deacetylated chitosan to cartilage microfra...

Journal: :Journal of biomedical materials research. Part A 2003
Jody Redepenning Guhanand Venkataraman Jun Chen Nathan Stafford

Composite coatings containing brushite (CaHPO(4). 2H(2)O) and chitosan were prepared by electrochemical deposition. The brushite/chitosan composites were converted to hydroxyapatite/chitosan composites in aqueous solutions of sodium hydroxide. The coatings ranged from approximately 1 to 15% chitosan by weight. Qualitative assessment of the coatings showed adhesion significantly improved over th...

2009
X. L. Tian D. F. Tian Z. Y. Wang F. K. Mo

Chitosan is a biocompatible, biodegradable and non-toxic polysaccharide polymer. It dissolves in water only if the pH is lower than 6.5. To extend its range of application, many water-soluble derivatives have therefore been prepared. In this research, chitosan-vitamin C complex was synthesized and characterized with Fourier transformed infrared spectroscopy, differential scanning calorimetry an...

Journal: :Biomacromolecules 2002
Keisuke Kurita Hiroyuki Ikeda Yuya Yoshida Manabu Shimojoh Manabu Harata

A simple and convenient procedure for chemoselectively protecting the amino groups of chitosan has been developed to provide N-phthaloyl-chitosan that is indispensable as a soluble N-protected precursor for further controlled modification reactions of chitosan. Although the conventional N-phthaloylation of chitosan in N,N-dimethylformamide was accompanied by partial phthaloylation of the hydrox...

2011
Jeen-Kuan Chen Chao-Hsien Yeh Lian-Chen Wang Tzong-Horng Liou Chia-Rui Shen Chao-Lin Liu

Chitosan is prepared by the deacetylation of chitin, the second-most abundant biopolymer in nature, and has applicability in the removal of dyes, heavy metals and radioactive waste for pollution control. In weight-reduction remedies, chitosan is used to form hydrogels with lipids and to depress the intestinal absorption of lipids. In this study, an experimental method was implemented to simulat...

2017
Jian Liu Lihui Gan Minnan Long

Chitosan has attracted much interest due to its special physical and chemical properties related to immunochemistry. The aim of this commentary is to appraise chitosan as an attractive functional polymer for medicine applications, which contributes to the development of chitosan for the immunochemistry. As reported, Chitosan has been used for immunochemistry purpose, such as functional food for...

2014
Hoda Jafarizadeh Ali Ghaz Jahanian

Chitosan is an attractive natural biopolymer from renewable resources with the presence of reactive amino and hydroxyl functional groups in its structure. Due to the good biocompatibility of chitosan, it can be used in magnetic-field assisted drug delivery, enzyme or cell immobilization and many other industrial applications. In the past decade, nanotechnology has been a considerable research i...

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