نتایج جستجو برای: chitosan

تعداد نتایج: 17212  

Journal: :Biomaterials 2013
Lirong Yang David A Zaharoff

Local delivery systems that provide sustained, high concentrations of antitumor cytokines in the tumor microenvironment while minimizing systemic dissemination are needed to realize the potential of cytokine-based immunotherapies. Recently, co-formulations of cytokines with chitosan solutions have been shown to increase local cytokine retention and bioactivity. In particular, intratumoral (i.t....

2017
Soher N. Jayash Najihah M. Hashim Misni Misran NA Baharuddin

BACKGROUND Osteoprotegerin (OPG) is used for the systemic treatment of bone diseases, although it has many side effects. The aim of this study was to investigate a newly formulated OPG-chitosan gel for local application to repair bone defects. Recent studies have reported that immunodetection of osteopontin (OPN) and osteocalcin (OC) can be used to characterise osteogenesis and new bone formati...

2013
Ann M. Walsh Torres Sweeney Bojlul Bahar John V. O’Doherty

Chitosan, a natural polysaccharide comprising copolymers of glucosamine and N-acetylglucosamine, has been shown to have anti-obesity properties. Two experiments (Exp. 1 and Exp. 2) were performed to determine the role of chitosan on dietary intake, body weight gain, and fat deposition in a pig model, as well as identifying potential mechanisms underlying the anti-obesity effect of chitosan. In ...

2013
Mazyar Sharifzadeh Mazyar Sharifzadeh Baei Mohammad Javad Hosseinzadeh Habibollah Younesi

Since maleic acid is capable of specially dissolving Chitosan, in this research the method of producing water lubricant nanoparticles in Chitosan solution, based on maleic acid has been studied. The resulting nanoparticles have a remarkable contact surface with the ordinary Chitosan form in absorbing metal ions, proteins and fat existing in Whey. After providing the 0.02, 0.03, 0.05 gr. density...

Journal: :Journal of agricultural and food chemistry 1999
M V Bhaskara Reddy J Arul P Angers L Couture

Chitosan treatment (2-8 mg/mL) of wheat seeds significantly improved seed germination to recommended seed certification standards (>85%) and vigor at concentrations >4 mg/mL, in two cultivars of spring wheat (Norseman and Max), by controlling seed-borne Fusarium graminearum infection. The germination was <80% in the control and >85% in benomyl- and chitosan-treated seeds. Seed-borne F. graminea...

2011
Yu-Lan Hu Wang Qi Feng Han Jian-Zhong Shao Jian-Qing Gao

BACKGROUND Although there are a number of reports regarding the toxicity evaluation of inorganic nanoparticles, knowledge on biodegradable nanomaterials, which have always been considered safe, is still limited. For example, the toxicity of chitosan nanoparticles, one of the most widely used drug/gene delivery vehicles, is largely unknown. In the present study, the zebrafish model was used for ...

Journal: :Applied and environmental microbiology 2014
Haini Zhang Hiroyuki Tachikawa Xiao-Dong Gao Hideki Nakanishi

In this study, we present a nonhazardous biological method of producing chitosan beads using the budding yeast Saccharomyces cerevisiae. Yeast cells cultured under conditions of nutritional starvation cease vegetative growth and instead form spores. The spore wall has a multilaminar structure with the chitosan layer as the second outermost layer. Thus, removal of the outermost dityrosine layer ...

2016
Annaian Shanmugam Kandasamy Kathiresan Lakshman Nayak

Chitosan is a commercially available derivative of chitin that has been extensively studied for its antimicrobial properties. In order to improve the water solubility and its biological activity, the chemical modification or derivatisation is attempted. In the present investigation, the chitosan prepared from the cuttlebone of Sepia kobiensis was being chemically modified by reacting it with or...

2009
Tsung-Lin Yang Tai-Horng Young

Chitosan is a widely used biocompatible biomaterial in the tissue regeneration, but its utility and application in the tissue morphogenesis of salivary gland remains unclear. The study aimed to explore the effects of chitosan on the epithelial morphogenesis of submandibular gland (SMG). With chitosan, the branching morphogenesis of the whole SMG explant was facilitated, and the morphogenetic-pr...

Journal: :Chemosphere 2004
Takeshi Gotoh Keiei Matsushima Ken-Ichi Kikuchi

Naturally occurring polysaccharides such as alginic acid and chitosan have been recognized as one of the most effective adsorbents to eliminating low levels of heavy metal ions from waste water stream. The present study intended to use alginic acid and chitosan simultaneously, which are expected to form a rigid matrix structure of beads due to electrostatic interaction between carboxyl groups o...

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