Introduction: It has been demonstrated that cholecystokinin sulfated octapeptide (CCK-8s) can affect synaptic transmission in the hippocampus. Because one of the major experimental models to understand the events happening in synaptic plasticity is To Study the long-term potentiation (LTP), we decided to investigate the effect of concomitant administration of CCK-8s and tetanic stimulation of S...

Intracerebroventricular injection of vasoactive intestinal polypeptide (VIP) into rat caused a temporary elevation of body temperature followed by a decrease to below the control level. Hypothermia induced by cholecystokinin octapeptide was abolished by simultaneous administration of VIP. Hypothermia following pentobarbital administration was reduced by successive injections of VIP. The results...

Cholecystokinin octapeptide (CCK-8) did not affect the behavioral syndrome of rats treated with pargyline and 5-hydroxytryptamine, while TRH produced a marked behavioral excitation under the same condition. However, the serotonin-potentiating effect of TRH was apparently suppressed by simultaneous administration of CCK-8.

cholecystokinin (cck), a peptide hormone found in the gut, is the most abundant peptide neurotransmitters in the brain, and its acute effects on the brain activity have been shown. in this study we aimed to evaluate the acute effects of cck on short-term synaptic plasticity in the dentate gyrus (dg) of the rat hippocampus. via stereotaxic surgery, the stimulating and the recording electrodes we...

The intravenous infusion of the octapeptide of cholecystokinin inhibited the response of the lower oesophageal sphincter to graded doses of pentagastrin in normal men. The possibility that the effects of these peptides on the lower oesophageal sphincter are only pharmacological and not physiological is discussed.

The purpose of this study was to evaluate the hormonal control of pyloric sphincter function. Studies were performed on both pyloric circular muscle, in vitro, and the human pylorus, in vivo. Full dose-response curves to gastrin I, cholecystokinin, and secretin were constructed for the pyloric muscle of the opossum studied at its length of optimal tension development, Lo. Both cholecystokinin a...

BACKGROUND/AIMS Resveratrol (3,5,4'-trihydroxystilbene) is a polyphenolic compound (stilbene) and a phytoalexin. The purpose of this study was to determine the mechanism which mediated the resveratrol-induced relaxation of cholecystokinin octapeptide- or KCl-induced tension in male guinea pig gallbladder strips. METHODS Gallbladder strips were prepared and suspended in in vitro chambers fille...