In animal tissues, cholesterol (cholest-5-en-3β-ol) is by far the most abundant member of a family of polycyclic compounds known as sterols (see also our web pages on plant sterols, oxysterols, etc.). It can also be described as a polyisoprenoid or a triterpene because of its biosynthetic origin. It was first recognized as a component of gallstones as long ago as 1770, while the great French li...

Background: By lowering LDL cholesterol levels, the risk of coronary heart disease (CHD) and other serious vascular events can be significantly reduced. In order to prevent cardiovascular illnesses (CVD), mainly disease, LDL-cholesterol (LDL-C) levels must tightly controlled on both a primary secondary level (CHD). Despite fact that patients in prevention experience higher absolute number ather...

This study evaluated the effects of physical activity on blood, growth, carcass, and meat quality finishing Alentejano (AL) pigs. Pigs, reared from ~87 to 160 kg in individual pens (no exercise area, NE group, n = 9) or an outdoor park (with WE 9), were fed commercial diets (85% ad libitum). pigs a (~400 m2) with feeding area separated drinking automatic waterer, forcing walk at least 800 m dai...

Abstract Background Momordica. charantia is popularly used as a medicinal herb in ethnomedicine for the management of cardiovascular diseases. In this study, we evaluated beneficial effects ethanolic extract M. (Linn.) experimentally induced disorders using cholesterol-fed Wistar rat. Methods Seventy-two experimental rats were randomly assigned into nine 9 groups 8 each and treated follows: Rat...

Abstract Aims/hypothesis Hyper-reflective crystalline deposits found in retinal lesions have been suggested to predict the progression of diabetic retinopathy, but nature these structures remains unknown. Methods Scanning electron microscopy and immunohistochemistry were used identify cholesterol crystals (CCs) human donor, pig mouse tissue. The effects CCs analysed bovine endothelial cells vit...

The interactions at the atomic level between small molecules and main components of cellular plasma membranes are crucial for elucidating mechanisms allowing entrance such species inside cell. We have performed molecular dynamics metadynamics simulations tryptophan, serotonin, melatonin interface zwitterionic phospholipid bilayers. In this work, we will review recent computer simulation develop...