Twin screw wet granulation (TSG) is gaining more attention and becoming an important process in the pharmaceutical industry. The process is widely implemented because of its flexibility, short residence time, and small equipment footprint. Past studies have shown that screw elements can have a significant impact on the performance of the TSG process. In addition, these studies identified that b...

Sister chromatid exchanges in chromosomes from human lymphocytes grown two replication cycles in medium containing 5-bromodeoxyuridine can be detected by fluorescence microscopy after staining with the bisbenzimidazole dye 33258 Hoechst. These exchanges are much more frequent than chromosome or chromatid breaks and appear to be partly but not entirely due to 5-bromodeoxyuridine incorporation. S...

High-fidelity chromosomal segregation requires the properly timed establishment of sister-chromatid cohesion mediated by the Cohesin complex, and its resolution at the metaphase-to-anaphase transition. We have examined cell-cycle progression in a yeast strain from which the origin recognition complex protein Orc2 was depleted after the assembly of prereplication complexes. We find that Orc2 dep...

LEE, SUNG WON. A Probability Model for Random Fiber Breakage. (Under the direction of JOHN WILLIAM BISHlR). Two fundamental questions in connection with the random breakage of fibers in a breakage system are set forth: Given a fiber group of any particular length, (1) What is the probability that a fiber of the length groups breaks at all? (2) What is the probability that a fiber breaks into s ...

Vertical roller mills (VRMs) are well-established grinding equipment for various tasks in the coal and cement industry. There are few studies on simulation of VRMs. In this research work, application of perfect mixing model for simulation of a VRM in a cement grinding plant was investigated. Two sampling surveys were carried out on the VRM circuit. The samples and data from the first survey wer...

Sister chromatid exchanges, which may reflect chromosome repair in response to certain types of DNA damage, provide a means of investigating the increased chromosome fragility characteristic of Fanconi's anemia. By a recently developed technique using 33258 Hoechst and 5-bromodeoxyuridine, it was observed that the baseline frequency of sister chromatid exchanges in phytohemagglutinin-stimulated...

in this paper shear behavior of two calcareous sands having different physical properties areinvestigated using drained and undrained triaxial tests. the investigated sands are obtained from two differentzones located in persian gulf, kish island and tonbak region. analysis based on energy aspects show thatfriction angle in these soils, having crushable particles, is formed of three components:...

The method of Matsumoto and Ohta [Matsumoto, K. & Ohta, T. (1992) Chromosoma 102, 60-65; Matsumoto, K. & Ohta, T. (1995) Mutat. Res. 326, 93-98] to induce large numbers of endoreduplicated Chinese hamster ovary cells has now been coupled with the fluorescence-plusGiemsa method of Perry and Wolff [Perry, P. & Wolff, S. (1974) Nature (London) 251, 156-158] to produce harlequin endoreduplicated ch...