Activation of AMP-activated protein kinase (AMPK)-α2 protects the heart against pressure overload-induced heart failure in mice. Although metformin is a known activator of AMPK, it is unclear whether its cardioprotection acts independently of an AMPKα2-dependent pathway. Because the role of AMPKα1 stimulation on remodeling of failing hearts is poorly defined, we first studied the effects of dis...

Pulmonary arterial hypertension (PAH) is a progressive disorder of the pulmonary vasculature characterized by the constriction of precapillary pulmonary arteries, leading to sustained elevated pressure in pulmonary vessels. The chronic strain and then failure of the right heart leads to significant morbidity and mortality in affected patients. In untreated patients the prognosis can be as poor ...

Pulmonary arterial hypertension (PAH) is a progressive disorder of the pulmonary vasculature characterized by the constriction of precapillary pulmonary arteries, leading to sustained elevated pressure in pulmonary vessels. The chronic strain and then failure of the right heart leads to significant morbidity and mortality in affected patients. In untreated patients the prognosis can be as poor ...