Sarcolemmal ATP-sensitive potassium channels (K(ATP)) act as metabolic sensors that facilitate adaptation of the left ventricle to changes in energy requirements. This study examined the mechanism by which K(ATP) dysfunction impairs the left ventricular response to stress using transgenic mouse strains with cardiac-specific disruption of K(ATP) activity (SUR1-tg mice) or Kir6.2 gene deficiency ...

This study examined whether endogenous extracellular adenosine acts to facilitate the adaptive response of the heart to chronic systolic overload. To examine whether endogenous extracellular adenosine can protect the heart against pressure-overload-induced heart failure, transverse aortic constriction was performed on mice deficient in extracellular adenosine production as the result of genetic...

The mechanisms mediating renal microvascular constriction induced by angiotensin II (Ang II) and endothelin (ET) have not been fully established. In the present study, we have determined the effects of isradipine, a dihydropyridine calcium antagonist, on Ang II- or ET-induced constriction of afferent arterioles (AAs) and efferent arterioles (EAs) using the isolated perfused hydronephrotic kidne...

To investigate whether exercise training can reverse age-related impairment of myogenic vasoconstriction in skeletal muscle arterioles, young (4 mo) and old (22 mo) male Fischer 344 rats were randomly assigned to either sedentary or exercise-trained groups. The roles of the endothelium and Kv1 channels in age- and exercise training-induced adaptations of myogenic responses were assessed through...

Background—Reactive oxygen species (ROS) may mediate pressure overload–induced myocardial hypertrophy. NADPH oxidase may be involved in this process, because its expression and activity are upregulated by pressure overload and because myocardial hypertrophy caused by a subpressor infusion of angiotensin is attenuated in mice deficient in the gp91 catalytic subunit of NADPH oxidase. Methods and ...

The terms ego constriction, ego inhibition, and ego restriction have not been clearly differentiated in their usage in the literature. In this paper a rationale for "ego constriction" as an entity distinct from both ego inhibition and ego restriction is given, despite its clear similarities to each. In a person with an ego inhibition, the ego inhibits a part of its own functioning because a par...

We explore robust methods of automatically quantifying constriction location, constriction degree and gestural kinematics of Italian short and long consonants using direct image analysis techniques applied to rtMRI data. Articulatory kinematics are estimated from correlated regional changes in pixel intensity. We demonstrate that these methods are capable of quantifying differences in constrict...

axial distributions of plasma and floating potentials, electron number density and the electron energy distribution function (eedf) have been measured in the double layer (dl) region of an he discharge constriction. excitation processes in the constriction region are studied. using a linearization method for the nonstationary balance equations and choosing appropriate discharge conditions, the ...

Chronic estrogen treatment increases endothelial vasodilator function in cerebral arteries. Endothelial nitric oxide (NO) synthase (eNOS) is a primary target of the hormone, but other endothelial factors may be modulated as well. In light of possible interactions between NO and prostaglandins, we tested the hypothesis that estrogen treatment increases prostanoid-mediated dilation using NOS-defi...