A chronic type of experimental hypertension has been produced in dogs by bilateral sinus area constriction. Hypophysectomy has a prolonged antihypertensive effect in dogs with persistent hypertension resulting from carotid sinus area constriction, while no decrease in mean arterial pressure is seen after hypophysectomy in normotensive control dogs. These findings suggest the possibility that al...

abstract a 2.5 year old girl is presented with both hands constriction bands leading to distal amputations and the rare deformity of shoulder duplication in the right side accompanying constriction skin marking over the affected shoulder. the cephalomedial scapula articulated with the clavicle and the caudolateral scapula articulated with humeral head. the most important physical finding which ...

Changes in potassium (K) concentration in erythrocytes (RBC) were investigated during the early developing stage (1 and 2 weeks after) and the chronic established stage (12 to 16 weeks after the renal artery constriction) in two-kidney (group 2H) and one-kidney Goldblatt hypertension (group 1H) of the rabbit. In both group 2H and group 1H, blood pressure was already elevated significantly durin...

Rats with chronic heart failure (CHF) develop increased myogenic constriction in mesenteric resistance arteries. Here we investigated increased myogenic constriction in relation to alterations in EDHF- and NO-mediated dilatation in CHF-rats. Male Spraque-Dawley rats were subjected to myocardial-infarction or sham-surgery. At 9-10 weeks after surgery, isolated mesenteric artery ring preparations...

Despite considerable evidence suggesting that hypertension contributes to the development and progression of atherosclerosis, the causative links remain unclear. We have tested the effects of chronic hypertension induced by suprarenal aortic constriction on the development of atherosclerosis in apolipoprotein E-deficient (Apoe-/-) mice. Compared with a sham operation, narrowing the aortic lumin...

DNA concentration in the left ventricle of 3-month-old rats 3 to 12 days after aortic constriction was similar to the values obtained in sham-operated litter mates (1.38 ± 0.03 /xg/mg wet weight). The total DNA content of the heart was thus increased proportionally to its enlargement. In chronic hypertrophy (2 to 4 months after aortic constriction), the DNA content was increased to a significan...

The present study reports the development and characterization of a murine model of right ventricular dysfunction following graded constriction in the pulmonary artery via microsurgical approaches. To analyze in vivo ventricular function, a technique of x-ray contrast microangiography was developed to allow the quantitative analysis of ventricular volumes and of ejection fraction in normal and ...