CONSTRICTION of one renal artery in the dog does not as a rule produce sustained hypertension. Removal of the contralateral kidney, or bilateral renal artery constriction is necessary for the production of permanent hypertension. On the other hand, sustained hypertension may be produced regularly in the rat by unilateral renal artery constriction. Tt has been postulated that, in the rat, long s...

Chronic hypertension caused by unilateral constriction of the renal artery in the presence of the opposite untouched kidney can be produced in the dog by progressive plication of the renal artery over a period of several hours. Twentythree female dogs were studied. Mean arterial blood pressure was measured in the unanesthetized recumbent dog by direct puncture of the femoral artery. Reproducibl...

This study was conducted to examine the role of nitric oxide (NO) in peripheral neuropathy induced by chronic constriction injury of sciatic nerve of rats by using NO precursor, NO donors and nitric oxide synthase (NOS) inhibitors. Chronic constriction injury of sciatic nerve of rats resulted in peripheral neuropathy as confirmed by nociceptive behavioural tests using mechanical, thermal and co...

• Chronic hypertension of moderate to marked severity has been produced in dogs by bilateral carotid sinus area constriction with specially devised plastic clamps.' 3 Three possible mechanisms have been proposed to explain this type of experimental hypertension: (a) an alteration in cerebral hemodynamics, presumably leading to the liberation of an increase in total peripheral resistance;'' (b) ...

The role of renal prostaglandins and the adrenergic nervous system in the control of renin release was studied in conscious dogs with thoracic caval constriction. Indomethacin reduced plasma renin activity (PRA) in intact animals with thoracic caval constriction by 43% but failed to change PRA after surgical renal denervation and during chronic propranolol administration; adrenergic blockade re...

Our group has developed a rat model of cardiac arrest and cardiopulmonary resuscitation (CPR). However, the current rat model uses healthy adult animals. In an effort to more closely reproduce the event of cardiac arrest and CPR in humans with chronic coronary disease, a rat model of coronary artery constriction was investigated during cardiac arrest and CPR. Left coronary artery constriction w...