background: compressive neuropathy of median nerve is relatively common but development of an hourglass like constriction is a rare phenomenon. the purpose of this study is to show morphologic changes of median nerve in advances carpal tunnel syndrome. methods: eighty patients with thenar atrophy, anesthesia and paresthesia of first, second and third finger and severe changes of emg‑ncv were ch...

OBJECTIVE Right ventricular (RV) failure is the leading cause of death in various cardiopulmonary diseases, including pulmonary hypertension. It is generally considered that the RV is vulnerable to pressure overload as compared with the left ventricle (LV). However, as compared with LV failure, the molecular mechanisms of RV failure are poorly understood, and hence therapeutic targets of the di...

Over eight years, 58 rural Nigerians with pericarditis were treated surgically in Zaria using basic surgical facilities. Eighteen patients had purulent pericarditis, associated with staphylococcal pneumonia in children, or pneumococcal pneumonia in adults. Treatment with antibiotics and prompt pericardiectomy appeared to be superior to drainage, since a quarter of those initially treated with s...

Background Nociception is maintained by genome-wide regulation of transcription in the dorsal root ganglia—spinal cord network. Hence, transcription factors constitute a promising class of targets for breakthrough pharmacological interventions to treat chronic pain. DNA decoys are oligonucleotides and specific inhibitors of transcription factor activities. A methodological series of in vivo–in ...

Clinical and hemodynamic observations are reported in 13 patients who demonstrated a distinct pathophysiologic form of compressive pericardial disease characterized by effusion into a free pericardial space associated with constriction of the heart by the visceral pericardium. The pericardial disease was idiopathic (nine patients) or subsequent to radiotherapy (four patients), with a maximal du...

The periapical area in teeth with chronic lesions is characterized by changes in the adjacent bone structure and periodontal ligaments, as well as in the cement and dentine. In a large percentage of cases, the apical physiological constriction is ether absent or expanded. The absence of a constriction makes it a challenge to achieve satisfactory treatment results.The present case report describ...

BACKGROUND Reactive oxygen species (ROS) may mediate pressure overload-induced myocardial hypertrophy. NADPH oxidase may be involved in this process, because its expression and activity are upregulated by pressure overload and because myocardial hypertrophy caused by a subpressor infusion of angiotensin is attenuated in mice deficient in the gp91phox catalytic subunit of NADPH oxidase. METHOD...

Aldosterone secretion (1) and aldosterone excretion in urine (2) are markedly elevated in dogs with chronic right heart failure and in dogs with chronic ascites secondary to thoracic caval constriction. It was suggested that the adrenal cortex is stimulated to secrete aldosterone by factors resulting from a high venous pressure and the consequent loss of fluid and electrolytes from the blood st...

Increasing evidence suggests that the cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) mediates the transduction and regulation of pain signals. However, the precise molecular mechanisms remain unclear. Studies show that release of fractalkine (FKN) from neurons plays a critical role in nerve injury-related pain. We tested the hypothesis that release of FKN from the CSF-contacting...

A rare case of non-puerperal chronic uterine inversion secondary to sub mucous fibroid in a 38-year-old woman is presented. There was complete uterine inversion with the incarcerated inverted uterus protruding through the vvgina beyond the vulva. The sub mucous fibroid was attached to the fundus. At laparotomy, a dimple with a constriction ring was found in the position of the uterus. The dista...