Background: Accumulating evidence suggests that the failing heart reprograms fuel metabolism toward increased utilization of ketone bodies and increasing cardiac delivery ameliorates dysfunction. As an initial step development therapies, we investigated effect chronic oral ester (KE) supplementation as a prevention or treatment strategy in rodent failure models. Methods: Two independent models ...

D. D. LUND, P. G. SCHMID, U. J. JOHANNSEN AND R. ROSKOSK~, JR. Biochemical Indices of Cholinergic and Adrenergic Autonomic Innervation in Dog Heart: Disparate Alterations in Chronic Right Heart Failure. Journal of Molecular and Cellular Cardiology (1982) 14, 419-425. Abnormal reflex sympathetic and parasympathetic control of heart rate occurs in canine right heart failure. Therefore, we investi...

Previous in vivo studies have shown that vasopressin, which releases the endothelium-derived relaxing factor and constricts coronary smooth muscle, produces augmented constriction of coronary microvessels perfused by mature collaterals. We hypothesized that chronic perfusion through collaterals produces endothelial dysfunction in the recipient vasculature. Mature collaterals were stimulated in ...

The present study aims to investigate the effects and underlying mechanisms of miRNA-145 (miR-145) in rat models of chronic constriction injury (CCI). Rats were randomly divided into control, sham, CCI, agomiRNA (agomiR)-normal control (NC) and agomiR-145 groups (n=25 in each group); in addition, 30 rats with CCI were divided into small hairpin (sh)RNA-NC and shRNA-ras responsive element bindin...

• During investigations of the effects of excercise and sympathomimetic amines on right ventricular function in unanesthetized dogs with normal or hypertrophied right ventricles, a circulatory state characterized by a supernormal stroke volume and cardiac output and by a decreased systemic vascular resistance was demonstrated in dogs studied 10 to 14 days after the release of chronic pulmonary ...

Constrictive pericarditis is present when a fibrotic, thickened, and adherent pericardium restricts diastolic filling of the heart. Several drugs can cause pericarditis, which can lead to chronic pericardial constriction. A case of constrictive pericarditis in a patient receiving the antiparkinsonian drug pergolide is reported.

while a wide array of pathological changes occur in cerebral arteries following subarachnoid hemorrhage (sah), the most consistent is endothelial damage. since the endothelium normally modulates reflexes that influence vascular tone, any damage to it may represent a significant contributor to cerebral vasospasm following sah. this experimental study investigates the correlation between endothel...