conclusions this study suggests that the il-7 level of chb patients may be related to tfh cells. in chb patients, il-7 possibly increases the level of tfh cells and hbv-specific cellular immune responses and thereby reduces the hbv dna level. background in patients with chronic hepatitis b (chb), the relation of interkeukin-7 (il-7) to either the t follicular helper cells (tfh cells) or to a sp...

abstract   background: hepatitis b virus infection is an important cause of liver morbidity and mortality worldwide. hdv changes the natural course of hbv. the prevalence of hdv infection wasn’t determined in the various groups of hbv infection (carriers, acute hepatitis, chronic hepatitis, cirrhosis and hcc) in iran. we aimed to research the prevalence of hepatitis d virus infection in various...

patients and methods using convenience sampling, people with chb attending four public liver clinics and one general practice in three australian jurisdictions between april and september 2013 completed a self-administered questionnaire about their feelings about having hepatitis b. results ninety-three people completed the survey. mean age was 45 years, 57% were men, and 93% were born overseas...

Background: Psychosocial issues and quality of life are important components at the patients diagnosed with chronic hepatitis B and C. Hepatitis is a chronic liver disease that can affect quality of life of patients. In this study, we compared the quality of life between patients with hepatitis B and C and finally presented a structural model about it. Methods: In a prospective analytic study,...

conclusions the results indicated that there was a positive association between susceptibility to chronic hbv infection and tnf-α polymorphism. in addition, hbv patients carrying -308 gg, -857 cc, and -863 aa genotypes with lower serum levels of tnf-α had an increased risk of infection. background the host genetic background regulates the natural history of chronic hepatitis b virus (hbv) infec...

conclusions family history as well as baseline bilirubin, ast and hbv dna levels can predict early virological response. the model provides a better tool for response prediction based on the four prognostic factors. results negative family history of hbv infection (p = 0.000235), baseline higher serum tbil (p = 0.038714) and ast (p = 0.020684) concentrations, and lower level of hbv-dna (p = 0.0...

introduction: hepatitis b is a potentially life-threatening infection that causes acute infection and chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma (hcc). interleukin-12 (il12) is responsible for activation of th1 immune responses, leading to possible clearance of hbv infection from the host’s body. the host’s immune-genetic background plays an important role in t...