background: hepatitis b virus (hbv) vaccination is a well-known, safe and effective way for protection against hbv infection; however, non-responders remain susceptible to infection with hbv. this is so important in patients with any kind of chronic liver disease, especially chronic hepatitis c virus (hcv) patients in whom acute hbv infection may lead to decompensation of liver disease. some of...

Background: Hepatitis viruses are non-cytopathic viruses that lead to the infection and pathogenesis of liver diseases as a result of immunologically mediated event. Objective: To investigate the expression of human inflammatory cytokines in chronic hepatitis B patients according to the severity of the infection. Methods: We recruited a total of 120 patients, 40 of whom from cirrhotic, 40 non-c...

Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B in...

Background:Tenofovir is among the first-line treatments for chronic hepatitis B (CHB) virus infection. We evaluated the efficacy of Tenofovir in the treatment of Iranian adult patients with CHB. Methods: In a retrospective study, we evaluated 154 HBsAg positive patients referred to Sadoughi hospital in Yazd-Iran for treatment ...

background: the mean platelet volume (mpv) is the most commonly used measure of platelet size and is a potential marker of platelet reactivity. in this study, we aimed to explore the relationship between hepatic  histopathology in viral hepatitis and mpv levels,which are associated with platelet count and activity. materials and methods: we performed a retrospective case-control study of baseli...

hepatitis b virus infection is a major public health problem worldwide. islamic republic of iran is a country in which hepatitisb prevalence is intermediate. the aim of this study is to assess prevalence of chronic hepatitis b infection in iran according to demographic characteristics. all cross-sectional studies concerning  revalence of chronic hepatitis b infection in iran were included irres...

Background: Serial measurement of  hepatitis B virus (HBV) DNA levels in the liver and its relation with liver damage and serum HBV DNA levels are guide to begin and/or end a treatment course. This study evaluated the relationship between liver hepatitis B DNA viral load with liver histology in patients with chronic hepatitis B (HBV). Methods:  Thirty patients with chronic anti-Hbe positive ...

Background and Aims: Viral hepatitis is a global health problem with a high mortality rate. Recently, a new Flavi-like virus, provisionally named hepatitis G virus (HGV), has been described. HGV does not induce an immune response that is consistently detectable by using recombinant proteins from prokaryotic expression, therefore studies have been conducted by using polymerase chain reaction (...

conclusions the inhibition of tregs is a novel therapeutic approach to cure chronically hbv infected patients. however, further studies are needed to investigate the safety and efficacy of this approach. results considering the increased levels of regulatory cytokines and also regulatory t cells (tregs) during chb, it seems that these cells are deeply involved in chb infection. the inhibition o...