OBJECTIVES To compare standard high flow oxygen treatment with titrated oxygen treatment for patients with an acute exacerbation of chronic obstructive pulmonary disease in the prehospital setting. DESIGN Cluster randomised controlled parallel group trial. SETTING Ambulance service in Hobart, Tasmania, Australia. PARTICIPANTS 405 patients with a presumed acute exacerbation of chronic obst...

Air pollution by diesel exhaust particles is associated with elevated mortality and increased hospital admissions in individuals with respiratory diseases such as asthma and chronic obstructive pulmonary disease. During active inflammation monocytes are recruited to the airways and can replace resident alveolar macrophages. We therefore investigated whether chronic fourteen day exposure to low ...

1 Suissa S, Ernst P, Vandemheen KL, Aaron SD. Methodological issues in therapeutic trials of COPD. Eur Respir J 2008; 31: 927–933. 2 Sin DD, Wu L, Anderson JA, et al. Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease. Thorax 2005; 60: 992–997. 3 Calverley PM, Anderson JA, Celli B, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmo...

BACKGROUND The World Health Organization has estimated that by 2030, chronic obstructive pulmonary disease will be the third leading cause of death worldwide. Most knowledge of chronic obstructive pulmonary disease is based on studies performed in Europe or North America and little is known about the prevalence, patient characteristics and change in lung function over time in patients in develo...

BACKGROUND AND AIM The multi-drug resistant-1 (MDR-1) gene is located on human chromosome 7 and encodes a glycosylated membrane protein that is a member of the ATP-binding cassette transporters superfamily. The aim of the study was to reveal the role of the C3435T MDR-1 gene polymorphism in chronic obstructive pulmonary disease. METHOD DNA samples from 41 patients with chronic obstructive pul...

1. Calverley PM, Boonsawat W, Cseke Z, Zhong N, Peterson S, Olsson H. Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease. Eur Respir J 2003; 22: 912–919. 2. Szafranski W, Cukier A, Ramirez A, et al. Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease. Eur Respir J 2003; 21: 74–81. 3. Calverley P, Pauwel...

The word ‘‘Obstructive’’ is misspelled in the article title. The correct title is: Increased Iron Sequestration in Alveolar Macrophages in Chronic Obstructive Pulmonary Disease. The correct citation is: Philippot Q, Deslée G, Adair-Kirk TL, Woods JC, Byers D, et al. (2014) Increased Iron Sequestration in Alveolar Macrophages in Chronic Obstructive Pulmonary Disease. PLoS ONE 9(5): e96285. doi:1...

Chronic Obstructive Pulmonary Disease (COPD) is characterized by irreversible airflow limitation in the lungs. COPD frequently coexist with Heart Failure (HF) but most patients go undiagnosed because of similarity symptoms. Data on prevalence HF are discrepant and scarce.

Chronic Obstructive Pulmonary Disease (COPD) is characterized by irreversible airflow limitation in the lungs. COPD frequently coexist with Heart Failure (HF) but most patients go undiagnosed because of similarity symptoms. Data on prevalence HF are discrepant and scarce.

Chronic Obstructive Pulmonary Disease (COPD) is characterized by irreversible airflow limitation in the lungs. COPD frequently coexist with Heart Failure (HF) but most patients go undiagnosed because of similarity symptoms. Data on prevalence HF are discrepant and scarce.