Background: Stress disturbs body weight and food intake, but the core mechanisms are not well understood. Study design: Experimental Materials Methods: The study was conducted in National Institute of Health (NIH), Islamabad Sixty male Sprague Dawley rats (mean wt 250 ± 50 grams) were used divided into 2 groups. Each group comprised 30 rats. Group I taken as control. II exposed to chronic stres...

background: in the recent years, various studies have shown a link between the free radicals, antioxidants and periodontal diseases. the purpose of the present study was to evaluate the oxidative stress and the antioxidant status present in the gingival tissue and plasma of patients with chronic periodontitis and to evaluate the antioxidant property of taurine. materials and methods: periodonta...

Stress begins in the brain and affects the brain, as well as the rest of the body. Acute stress responses promote adaptation and survival via responses of neural, cardiovascular, autonomic, immune and metabolic systems. Chronic stress can promote and exacerbate pathophysiology through the same systems that are dysregulated. The burden of chronic stress and accompanying changes in personal behav...

Metastasis to the liver is a main factor in colorectal cancer mortality. Previous studies suggest that chronic psychological stress is important in cancer progression, but its effect on liver metastasis has not been investigated. To address this, we established a liver metastasis model in BALB/c nude mice to investigate the role of chronic stress in liver metastasis. Our data suggest that chron...

Stress is now recognized as a universal premorbid factor associated with many risk factors of various chronic diseases. Acute stress may induce an individual's adaptive response to environmental demands. However, chronic, excessive stress causes cumulative negative impacts on health outcomes through "allostatic load". Thus, monitoring the quantified levels of long-term stress mediators would pr...

Chronic psychological stress appears to accelerate biological aging, and oxidative damage is an important potential mediator of this process. However, the mechanisms by which psychological stress promotes oxidative damage are poorly understood. This study investigates the theory that cortisol increases in response to an acutely stressful event have the potential to either enhance or undermine p...

OBJECTIVE To determine whether the association between self-rated or interviewer-rated recent acute stress exposures and low-grade inflammation and daily cortisol production in adolescents is moderated by chronic stress ratings. METHODS Acute and chronic stress exposures were assessed in 261 adolescents aged 13 to 16 years using a semistructured life stress interview. The negative impact of a...

Background: The increase of stress following the technological improvements appears to be an important factor that causes organs disorders like genital system. Therefore the present study was conducted to investigate the effects of chronic multiple sequential stress on rat epididim. Materials and Methods: 18 Wistar rats were divided randomly into two equal groups. In animals under stress, the m...

BACKGROUND Chronic stress is associated with cardiac remodeling; however the mechanisms have yet to be clarified. OBJECTIVE The purpose of this study was test the hypothesis that chronic stress promotes cardiac dysfunction associated to L-type calcium Ca2+ channel activity depression. METHODS Thirty-day-old male Wistar rats (70 - 100 g) were distributed into two groups: control (C) and chro...

BACKGROUND AND PURPOSE Chronic stress is associated with increased stroke risk. However, the underlying pathophysiological mechanisms are poorly understood. We examined the effects of chronic stress on endothelial function and ischemic brain injury in a mouse model. METHODS 129/SV mice were treated with glucocorticoid receptor antagonist mifepristone (25 mg kg(-1)/d) or vehicle and exposed to...