Doripenem, a parenteral carbapenem with broad-spectrum activity against aerobic Gram-negative and Gram-positive and anaerobic pathogens, is currently approved for use in adults in the United States and European Union. Single-dose doripenem pharmacokinetics in 52 infants <12 weeks in chronological age were investigated in this phase 1 study. Hospitalized, medically stable infants <12 weeks in ch...

We present a review of a population of 114 immigrant Moroccan males for which an age estimation was requested. The subjects' real chronological age was confirmed by the Moroccan Embassy in Spain. The confirmed age range was between 13 and 25, with an average age of 18.1 years and a standard deviation of 2.03. The following tests were performed to arrive at the forensic estimation of age: genera...

INTRODUCTION Dental age estimation methods are of particular value because teeth are highly resistant to mechanical, chemical, or physical impacts and time. Teeth are the strongest parts in the human body and are therefore very resistant to external influences, such as extreme temperatures, explosions, and other extreme conditions, which make them available for extensive postmortem periods. A...

Multicellular life evolved from simple unicellular organisms that could replicate indefinitely, being essentially ageless. At this point, split into two fundamentally different cell types: the immortal germline representing an unbroken lineage of division with no intrinsic endpoint and mortal soma, which ages dies. In review, we describe as clock-free soma clock-bound discuss aging respect to t...

OBJECTIVE This study was aimed to evaluate the dental age in Saudi children from panoramic radiographs using the Demirjian method to estimate their chronological age. MATERIALS AND METHODS This retrospective cross-sectional study consisted of 1902 panoramic radiographs of 955 boys and 947 girls between the ages of 3-17 years. All children were placed in the age group closest to their chronolo...