Rhythmicity is a ubiquitous phenomenon. Rhythmic temporal patterns are considered and important factor in therapeutics as effective treatments should work in conjunction with body's clocks. Te concept of chronobiology is well evidenced by the cyclic alterations of dosas in the body. The Ayurvedic way of living as well as healing has been developed keeping in mind these biological clocks so as t...

Trichlormethiazide was given orally at 1200 hrs or 2400 hrs to rats. Its diuretic effects were greater at 1200 hrs than at 2400 hrs. There were significant correlations between urinary trichlormethiazide and its effects in both trials. The regression lines of two trials did differ. These findings indicate that the effects of trichlormethiazide vary with its administration time. Time-dependent v...

Most facets of mammalian physiology and behavior vary according to time of day, thanks to endogenous circadian clocks. Therefore, it is not surprising that many aspects of pharmacology and toxicology also oscillate according to the same 24-h clocks. Daily oscillations in abundance of proteins necessary for either drug absorption or metabolism result in circadian pharmacokinetics, and oscillatio...