Pharmacokinetics of hypertension medications is significantly affected by circadian rhythms that influence absorption, distribution, metabolism and elimination. Furthermore, their pharmacodynamics ingestion-time differences in kinetics comprising the biological mechanism 24 h blood pressure (BP) pattern. However, guidelines do not recommend time to treat patients with medications. We conducted ...

The epidermal growth factor receptor (EGFR), a ubiquitously expressed receptor tyrosine kinase, is recognized as a key mediator of tumorigenesis in many human epithelial tumors. Erlotinib is tyrosine kinase inhibitor approved by FDA for use in oncology. It inhibits the intracellular phosphorylation of tyrosine kinase associated with the EGFR to restrain the development of the tumor. To investig...

Chronobiology of rheumatoid arthritis (RA) was studied using a standard adjuvant arthritis animal model. Chronopharmacology of ketoprofen, and its solid dispersion forms was also studied. Temporal variations in the degree of articular inflammation (paw volume) and progression of articular destruction were studied by injecting Freund's Complete Adjuvant (FCA) at 0800 and 2000 hrs. Temporal varia...

Circadian rhythms in body temperature, locomotor activity, and the circadian changes of plasma and pineal melatonin content were investigated in B6D2F(1) mice synchronized by 12 h of light and 12 h of darkness. During 8 wk continuous recording, activity and temperature displayed a marked stable and reproducible circadian rhythm, with both peaks occurring near the middle of darkness. Both 24- an...

Many of the drugs leave the market due to their adverse effects than their therapeutic effects. If the pharmacology of the drug and its adverse effect is Circadian Time (CT) dependent, it can be modulated by altering the time of administration of drugs. Chronopharmacology describes the effect of drugs in terms of time of administration. Its main objective is chronotherapy (time based treatment)...

S53. 5 Radiotelemetry in Cardiovascular Chronopharmacology in Transgenic and Knockout Rats and Mice BjÊern Lemmer; Institute of Experimental and Clinical Pharmacology and Toxico-l ogy, University of Heidelberg; Maybachstr. 14, 68169 Mannheim, Germany In freely moving rodents radiotelemetry has improvedknowledge on circadian regulation of cardiovascular system ( blood pressure BP, heart rate HR,...

. Moreno PR, Fuster V. The year in atherothrombosis. J Am Coll Cardiol 2004;44:2099–110. . Muller JE, Stone PH, Turi ZG, et al. Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med 1985; 313:1315–22. . Abo T, Kawate K, Itoh K, et al. Studies on the bioperiodicity of the immune response. Circadian rhythms of human T, B and K cell traffic in the peripheral bl...