نتایج جستجو برای: cigarette smoke

تعداد نتایج: 86370  

2011
Wouter D. van Dijk Simone Gopal Paul T. J. Scheepers

Cigarette smoke is a complex mixture of smoke constituents, often characterised by size-resolved particle distributions. Since descriptions of ultrafine particles <50 nm are absent, our aim was to explore the existence of these nanoparticles in fresh and undiluted cigarette smoke. We measured undiluted smoke particles real-time by a scanning mobility particle sizer with Faraday cup electrometer...

Journal: :American journal of respiratory and critical care medicine 2006
Stefano Carnevali Fabrizio Luppi Domenico D'Arca Andrea Caporali Maria Paola Ruggieri Maria Vittoria Vettori Andrea Caglieri Serenella Astancolle Francesca Panico Pierpaola Davalli Antonio Mutti Leonardo M Fabbri Arnaldo Corti

RATIONALE Cigarette smoke causes injury to lung fibroblasts, partly by means of oxidative stress, and oxidative stress can lead to various lung diseases, such as chronic obstructive pulmonary disease. Clusterin is a widely distributed protein with many functions, including cellular protection in response to oxidative stress. OBJECTIVES To determine whether clusterin is involved in the defense...

Journal: :International journal of clinical and experimental medicine 2015
Dan Xu Chun Wan Tao Wang Panwen Tian Diandian Li Yanqiu Wu Siyi Fan Lei Chen Yongchun Shen Fuqiang Wen

Cigarette smoke-induced airway inflammationmucus over-production is one of the most important pathogenic features of chronic airway diseases. This study aimed to investigate the effect of berberine, a plant alkaloid with strong anti-inflammatory property, on cigarette smoke-induced airway inflammation and mucushypersecretion in mice. Mice with exposure to cigarette smoke wereintraperitonealy in...

1999
A. FELIX OFULUE

Ofulue, A. Felix, and Mary Ko. Effects of depletion of neutrophils or macrophages on development of cigarette smoke-induced emphysema. Am. J. Physiol. 277 (Lung Cell. Mol. Physiol. 21): L97–L105, 1999.—The aim of this study was to ascertain the putative roles of neutrophils or macrophages in the pathogenesis of cigarette smoking-induced emphysema on the basis of effects of anti-neutrophil (anti...

Journal: :The European respiratory journal 1999
J L Wright J P Sun A Churg

Cigarette smoke is known to cause acute increases in airway resistance, but the mechanisms behind this effect are unknown. Lung explants were utilized to examine the constrictive effects of acute cigarette smoke exposure on bronchioles from rats in vitro that had or had not been previously exposed to cigarette smoke in vivo. It was found that smoke induced a small but consistent degree of contr...

Journal: :Thorax 1994
J A Dye K B Adler

Chronic inhalation of cigarette smoke is associated with mucus hypersecretion, mucus pooling, pulmonary connective tissue damage, and chronic airflow obstruction. Cigarette smoke has therefore been causally linked to the development of chronic obstructive pulmonary disease (either chronic bronchitis or emphysema),' increased airway responsiveness,2 exacerbations of asthma,3 impaired pulmonary i...

Journal: :Acta medica Okayama 1995
K Furuno M Okazaki K Eto H Kawasaki Y Gomita

The effects of acute exposure to cigarette smoke and systemic administration of nicotine on intestinal propulsion were investigated in rats. The propulsive activity was measured as migration of charcoal powder in the intestine. This activity was suppressed by acute exposure (10 min) to cigarette smoke and by nicotine (0.5 mg/kg x 2, s.c.) administration. This intestinal suppression was more mar...

Journal: :International journal of clinical and experimental medicine 2015
Yongchun Shen Panwen Tian Diandian Li Yanqiu Wu Chun Wan Ting Yang Lei Chen Tao Wang Fuqiang Wen

Cigarette smoke-induced airway inflammation is one of the most important features of chronic airway diseases. Studies suggest that chrysin possesses strong anti-inflammatory properties and this study aimed to investigate the effect of chrysin on cigarette smoke-induced airway inflammation in mice. Mice with exposure to cigarette smoke were intraperitonealy injected with chrysin (10, 20 mg/kg·d)...

Journal: :The European respiratory journal 2010
E Mortaz I M Adcock K Ito A D Kraneveld F P Nijkamp G Folkerts

Chronic obstructive pulmonary disease (COPD) is a major health problem and cigarette smoke is the main risk factor for the development of COPD. The characteristic changes in airway morphology, inflammatory cell infiltration and mediator expression in COPD may result from direct effects of cigarette smoke on airway cells. Toll-like receptors (TLRs) are key elements in pathogen recognition by the...

Journal: :Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2011
Liqin Zhang David L Ashley Clifford H Watson

INTRODUCTION Heterocyclic aromatic amines (HAAs) represent an important class of carcinogens in mainstream cigarette smoke. Accurate HAA quantification is challenging because of their relative low abundances and numerous chemical interferences that arise naturally from thousands of the constituents present in cigarette smoke. We have developed and validated a straightforward high-throughput met...

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