Cisplatin is one of the most useful chemotherapeutics which performs its cytotoxic effectvia accumulation of platinum resulting in oxidative stress, and destruction of cell DNA. Thiscould probably cause secondary cancers in healthy tissues. Lipocalin2 (Lcn2) is a protein whichits expression is increased in oxidative stresses. Therefore, the present study was performedto evaluate the protective ...

Cisplatin efficacy is dependent on dose. The cisplatin-induced apoptosis pathway can go through the ER stress which will activate Bax and Bak (proapoptosis) causing calcium homeostasis disorders to occur. Glutamine protective effect caspase-12 expression prevention of apoptotic events in renal proximal tubular epithelial cells unknown. This further study analyzes effects intravenous glutamine c...

O‑GlcNAcylation is a dynamic and reversible post‑translational modification of proteins that modulated by O‑GlcNAc transferase (OGT) O‑GlcNAcase (OGA). Alterations in the protein expression O‑linked β‑N‑acetylglucosamine (O‑GlcNAc) can be induced multiple factors. However, little known effects chemotherapeutic agents on relevant molecular me...

background nephrotoxicity and hepatotoxicity are side effects of cisplatin (cp) therapy. objectives we investigated the role of gender in cp-induced nephrotoxicity and hepatotoxicity. materials and methods low dose of cp (1 mg/kg/day; ip) was administered daily to male and female wistar rats for 15 consecutive days. serum creatinine (cr), blood urea nitrogen (bun), malondialdehyde (mda), nitric...

introduction: cell culture is a process in which the cells ware isolated from original tissue, dispersed in liquid media and then placed in culture plate where the cells adhere together and propagate. today, this method is used for assessment of cell toxicity, its mechanisms and effect of different compounds on intracellular components. methods: clonogenic assay was used for assessment of cell ...

Objective(s): Cisplatin is an effective antineoplastic agent; its clinical utility, however, is limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective effects of tangeretin, a citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced renal toxicity of rats.Materials and Methods: Tangeretin was injected intra...

ginger, the rhizome of zingiber officinalis, has long been used as herbal medicine for its antiemetic effect. for evaluating the effect of zingiber officinalis on nausea and vomiting (n and v) in patients receiving cisplatin based regimens, a randomized double-blind placebo-controlled cross-over clinical trial was carried out in patients receiving cisplatin in combination with other chemotherap...

Objective: Cancer is the most common cause of death after cardiovascular diseases. Cisplatin used in types cancer produces neurotoxicity. In this study, we aimed to investigate effects pomegranate peel extract (1) different doses, as potent antioxidants, on prevention neurotoxicity due cisplatin, which frequently treatment. Methods: our newborn rat cortex was used. 2 hours following application...

Chemotherapy is one of the basic methods cancer treatment, which uses compounds with a broad spectrum activity. Among diverse group cytostatic drugs, platinum derivatives play an important role in therapy, including cisplatin. Cisplatin first generation drug approved medicine 1980s. The mechanism anti-tumor activity cisplatin based on pro-apoptotic and antiproliferative Cisplatin, through forma...

Objective(s): This paper aims to investigate synergistic inhibition of polysaccharide from Sepia esculenta ink (SIP), a newly isolated marine polysaccharide in our laboratory, on breast cancer MDA-MB-231 cells exposed to cisplatin. Materials and Methods: Cell viability of MDA-MB-231 cells was determined by CCK 8 assay. Median-effect concentration was analyzed using Chou-Talalay method that was ...